Late endothelialization of first generation pharmacological stents may predispose thrombosis. Both the drug and the polymer of the platform may affect the rate at which this occurs. This is a prospective, multicenter study which randomized 44 patients with acute coronary syndrome to receive sirolimus-eluting stent with bio-absorbable polymer versus zotarolimus-eluting stent with permanent polymer. The coating of the struts was assessed by OCT and the vasodilator response using CFR.
There were no differences in clinical characteristics of patients but there was a significant difference in favor of the stent with bio-absorbable polymer in the number of struts not covered by OCT, (189/3.9% versus 495/8.9%, p <0.001), as well as in the amount of badly placed struts, (292/5.3 126/2.6% versus %, p <0.001).
Conclusion: The sirolimus-eluting stent with bio-absorbable polymer showed better covered struts by endothelium after three months of angioplasty compared with the zotarolimus eluting stent with permanent polymer.
Tuomas Kiviniemi
2013-05-22
Original title: Early vascular healing of hybrid sirolimus-eluting stents with bioabsorbable polymer versus zotarolimus-eluting stents with durable polymer – HATTRICK-OCT Trial.
