The aim of this study was to observe the rate of thromboembolic and hemorrhagic events in a period of 2 years in 167 patients undergoing appendage occlusion with Amplatzer device. 

Appendage occlusion in patients with contraindication to anticoagulation is a safe technique associated with less embolic and bleeding events than expected according to the risk scores. Bleeding incidence of post occlusion was also reduced and more evident in the second year of follow-up. 

J.R. Lopez-Minguez
2014-05-22

Title: The IBERIAN registry: 2-year clinical outcome after left atrial appendage closure with the Amplatzer cardiac plug device in patients with non-valvular atrial fibrillation and contraindications for anticoagulation therapy