I-LOVE-IT2: Drug-eluting stents with a permanent polymer versus biodegradable in the same cobalt chromium platform

There is no strong evidence in the literature that the polymer type isolated (permanent or degradable) influences clinical outcomes after angioplasty and if the time of double anti-aggregation should be different with the degradable polymer. This work, with non-inferiority design, aimed to compare the sirolimus-eluting biodegradable polymer stent (Tivoli) versus the permanent polymer sirolimus-eluting stent (Firebird 2). The primary end point was a composite of cardiac death, myocardial infarction related to the vessel and target vessel revascularization. 

2737 patients from 32 Chinese centers were randomized, demonstrating non-inferiority of the biodegradable polymer stent at 12 months with 6.3% events versus 6.1% of the permanent polymer stent. Comparing each component of the primary end point individually no significant differences were observed between the two devices. 

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Bo Xu
2014-09-17

Original title: A Prospective, Randomized Trial of a Biodegradable Polymer, Cobalt Chromium, Sirolimus-Eluting Stent Versus a Durable Polymer, Cobalt Chromium, Sirolimus-Eluting Stent in Patients with Coronary Artery Disease.

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