900 patients with asymptomatic diabetes mellitus were randomized to CT angiography vs. Standard management. Primary end point was a combination of death, infarction and unstable angina.
63% of patients randomized to CT angiography presented some degree of heart disease and 4.7% presented severe lesions. This resulted in more coronary interventions, more use of statins and a significant reduction of blood pressure and LDL levels compared to the control group; however, there was no significant reduction of event (7.6% vs 6.2%; p=0.38).
Conclusion
In this population of high risk asymptomatic diabetic patients, routine CT angiography increased the use of statins and revascularization procedures but was not able to reduce events.
3_joseph_muhlestein_presentacion
Joseph B Muhlestein
2014-11-18
Original title: Screening For Asymptomatic Obstructive Coronary Artery Disease Among High-Risk Diabetic Patients Using Coronary CT Angiography: Primary Results of FACTOR-64, a Randomized Controlled Trial.