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GIANT: Evaluation of the genetic profile of CYP2C19 in patients undergoing primary angioplasty

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The aim of this study was to evaluate the clinical impact resistance thienopyridines through genetic analysis of CYP2C19 receptor. The primary endpoint was  a combination of mortality, myocardial infarction, stent thrombosis in the resistance group (few responders) versus non-resistant (responders) to the thienopyridines. 1445 patients were included of which 22% were considered few responders. There was no difference in the primary endpoint between responders and nonresponders (3% for both groups, P = .83).

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Bernard R. Chevalier
2013-10-31

Original title: GIANT: A Prospective Registry Study of CYP2C19 Genetic Profiling for Thienopyridine Management After Primary PCI in Acute Myocardial Infarction

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