GIPS -III: Metformin does not improve ejection fraction in non-diabetic patients undergoing primary angioplasty

There are experimental studies suggesting that metformin admin before and during ischemia and reperfusion could help to preserve left ventricular function regardless of glycometabolic state.In observational studies, the concomitant use of metformin is associated with a lower peak CK MB and troponin.380 nondiabetic patients undergoing primary angioplasty for acute coronary syndrome study with ST segment elevation were randomized to receive metformin 500 mg 2 times per day or placebo for 4 months. The primary end point of the study was the left ventricular function at 4 months measured by nuclear magnetic resonance.At 4 months, the ejection fraction in the metformin group was 53.1 % versus 54.8 % in the placebo group (p = 0.1).

Conclusion

Metformin does not improve ejection fraction in non diabetic patients undergoing primary angioplasty.

Article

2_chris_lexis_slides
Chris PH Lexis
2014-03-31

Original title: Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes (The GIPS-III Randomized Clinical Trial).

More articles by this author

MSC -HF Trial: Auto mesenchymal cell transplantation may improve ventricular function in patients with heart failure of ischemic cause

This study is a phase 2, randomized 2:1, double blind, and placebo-controlled included 59 patients with advanced heart failure of ischemic etiology undergoing autologous...

ZEUS Trial: Patients with increased risk of bleeding may benefit from eluting stents Zotarolimus

The use of drug-eluting stents versus bare metal stents is controversial in some clinical situations in patients at high risk of bleeding.This study randomized...

NEXT Trial: Biodegradable polymer stent (Nobori) was similar to the permanent polymer stents (Xience / Promus) at 2 years.

This multicenter work from Japanrandomized 3200 patients to receive biodegradable polymer biolimus eluting stent(Nobori) or everolimus-eluting stent with permanent polymer (Xience / Promus). The...

SIRS Trial: Methylprednisolone does not decrease mortality and increase the risk of stroke in patients undergoing cardiac surgery

Cardiac surgery with cardiopulmonary bypass results in an inflammatory response of the body that is usually associated with adverse outcome. The preventive use of...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

Evolution of Small Balloon-Expandable Valves

Small aortic rings (20 mm) have posed a significant challenge for both surgery and transcatheter aortic valve implantation (TAVI) due to their association with an...

TCT 2024 | Asymptomatic Severe Aortic Stenosis: What Should Be our Approach?

Approximately 3% of the population over 65 years old has aortic stenosis. Current guidelines recommend valve replacement for patients with symptoms or an ejection...

TCT 2024 | FAVOR III EUROPA

The study FAVOR III EUROPA, a randomized trial, included 2,000 patients with chronic coronary syndrome, or stabilized acute coronary syndrome, and intermediate lesions. 1,008...