IN.PACT Global Study: Pharmacological balloon in long lesions of the Superficial Femoral Artery (SFA)

Long lesions (≥ 15 cm), total occlusions, and in-stent restenosis represent a unique treatment challenge in peripheral vascular disease. IN.PACT Global study is a prospective, multicenter, single arm designed to evaluate the safety and efficacy of IN.PACT® ADMIRAL® drug eluting balloon for the treatment of superficial femoral and popliteal arteries in a real-world population.

A subset of patients underwent Doppler ultrasound scans at 12 months to assess the patency, being divided these patients into three groups according to the original injury (stent restenosis, de novo lesions ≥ 15 cm, and a total occlusions ≥ 5 centimeters).

Of the total, 157 patients were followed by Doppler at 12 months and originally presented a de novo lesion ≥ 15 cm. 41% of these patients had a history of diabetes and the average lesion length reached 26.4 ± 8.61 cm. The primary patency defined as the absence of revascularization of the target lesion justified by the clinic, was 91.1%. No major amputations within 12 months were observed. The combined safety end point (no mortality, no amputation, and revascularization) at 12 months was 94%.

Conclusion

The study showed a low rate of re-intervention and high permeability to 12 months in this subgroup of complex patients treated with the paclitaxel eluting balloon.

11_dierk_scheinert
Dierk Scheinert
2015-05-20

Original title: Drug Coated Balloon Treatment for Patients with Intermittent Claudication: New Insights from the IN.PACT Global Study Long Lesion (≥ 15 cm) Imaging Cohort.

More articles by this author

NONSTEMI: Superiority of early angioplasty in non-ST elevation myocardial infarction

The European guidelines recommend revascularization within 24 hours in high-risk patients with No ST segment elevation myocardial infarction. It is unclear whether these patients...

TOTAL stroke: increased risk of stroke with thromboaspiration

There are many doubts about the benefit of manual thromboaspiration, not only in terms of improvement of the clinical end point but also the...

PARTNER II: Less oversizing to reduce paravalvular failure with the new generation of SAPIEN 3

The new generation SAPIEN 3 valve was designed to reduce paravalvular aortic regurgitation. The objective of this work was to evaluate the influence of...

Angiographic TOTAL: Sub angiography studio of TOTAL

Myocardial blush is a predictor of mortality after primary angioplasty. Small studies showed a degree of improvement blush with manual thromboaspiration. The present work...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

Severe Tricuspid Regurgitation: Surgical vs. Transcatheter Edge-to-Edge Repair

While highly prevalent, tricuspid regurgitation is a notably undertreated valvulopathy. Its progression has been associated with higher mortality and significant disability. According to the...

ACCESS-TAVI: Comparing Post TAVR Vascular Closure Devices

Transcatheter aortic valve replacement (TAVR) is a well-established option to treat elderly patients with severe symptomatic aortic valve stenosis. Technical advances and device development...

Endovascular Treatment of Iliofemoral Disease for the Improvement of Heart Failure with Preserved Ejection Fraction

Peripheral artery disease (PAD) is a significant risk factor in the development of difficult-to-treat conditions, such as heart failure with preserved ejection fraction (HFpEF)....