PRATO ACS: Rosuvastatin reduces the incidence of contrast nephropathy in patients with acute coronary syndrome who receive early invasive strategy

The aim of this study was to determine whether patients without ST-segment elevation acute coronary syndromes who were not taking statins previously, can receive high doses of rosuvastatin before coronary angiography or angioplasty and if this action could exert protection in renal function and reduce the incidence of contrast-induced nephropathy (CIN).

This prospective study randomized 543 patients without ST segment elevation acute coronary syndrome to receive rosuvastatin, (271 patients), or atorvastatin, (272 patients), twenty-four hours before contrast exposure. The primary endpoint was a creatinine increase greater than or equal to 0.5 mg/dl or greater or equal to 25% after seventy-two hours of contrast exposure. The two groups had similar clinical features and proceedings. The incidence of contrast-induced nephropathy (CIN) was 6.7% in the rosuvastatin group versus 15.1% in the control group, (p = 0.001). The benefit is maintained even for different definitions of contrast-induced nephropathy (CIN). The rosuvastatin group also had lower rates of adverse clinical events at thirty days, (persistent renal damage, need for dialysis, myocardial infarction, stroke or death), of 3.6% versus 7.9% (p = 0.036). 

Conclusion: Patients’ distress without ST-segment elevation acute coronary syndromes who undergo early invasive strategy will benefit from high doses of rosuvastatin from baseline, exerting additional benefit in the prevention of CIN and with better short-term clinical outcomes.

anna_toso_acc2013
Anna Toso
2013-03-12

Original title: Early High-Dose Rosuvastatin for Contrast-Induced Nephropathy Prevention in Acute Coronary Syndrome – PRATO ACS Study

 

More articles by this author

Possible benefit for patients with acute myocardial infarction but without ventricular dysfunction.

Background: To evaluate whether the administration of eplerenone 24 hours after an acute myocardial infarction (AMI) in patients without heart failure reduces mortality and...

SELECT ACS: The Inclacumab seems to reduce myocardial injury post angioplasty

P-selectin is an adhesion molecule involved in the interactions between endothelial cells, platelets and leukocytes. Inclacumab is a recombinant monoclonal antibody against P-selectin, a...

Possible benefit for patients with acute myocardial infarction but without ventricular dysfunction.

Background: To evaluate whether the administration of eplerenone 24 hours after an acute myocardial infarction (AMI) in patients without heart failure reduces mortality and...

CHAMPION PHOENIX: Cangrelor compared with clopidogrel improves efficiency without increasing bleeding in patients undergoing angioplasty

Background: Oral antiplatelet agents have a limitation in their duration of action and bioavailability. Cangrelor is an intravenous adenosine diphosphate (ADP) inhibitor that has...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

ACC-2025 Congress Second Day Key Studies

BHF PROTECT-TAVI (Kharbanda RK, Kennedy J, Dodd M, et al.)The largest randomized  trial carried out across 33 UK centers between 2020 and 2024, assessing...

ACC 2025 | FAME 3: FFR Guided PCI vs CABG 5 Year Outcomes.

Earlier studies comparing percutaneous coronary intervention (PCI) vs coronary artery bypass graft (CABG) have shown fewer events at long term for the surgical strategy.  However,...

ACC 2025 | API-CAT: Reduced vs. Full Dose Extended Anticoagulation in Patients with Cancer Related VTE

The risk of cancer related recurrent venous thromboembolism (VTE) will drop over time, while bleeding risk will persist. At present, it is recommended we...