Angina pectoris without stenosis in the epicardial coronary arteries is a common problem with several possible underlying causes. The main purpose of this work was to test the hypothesis that stratified medical therapy guided by an interventional diagnostic procedure might improve outcomes.
Patients without coronary lesions and with angina were immediately randomized 1:1 to an interventional group (stratified medical therapy) or a control group (standard treatment).
The coronary vasoreactivity test was carried out through the bolus infusion (100 µm) of incremental concentrations of acetylcholine, followed by vasospasm provocation. The primary endpoint was change in symptoms according to the Seattle Angina Questionnaire.
The interventional group featured 76 patients and the control group included 75. At 6 months, there was a mean improvement of 11.7 units in the Seattle Angina Questionnaire score, as well as improvement in quality of life. There was no difference as regards cardiac adverse events.
Original title: A Randomized Trial of Invasive Coronary Function Testing in Patients with Angina and Nonobstructive Coronary Artery Disease.
Presenter: Tom J. Ford.
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