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TCT 2012.

You will find here the best presentations and highlights of the Late Breaking Clinical Trials session during the TCT 2012

ISAR-LEFT MAIN 2: Everolimus-eluting stents versus Zotarolimus eluting stents in the treatment of the unprotected left coronary trunk.
Summary: Second-generation drug-eluting stents have shown better results than their predecessors. In this study we compare two second-generation drug stents in patients with unprotected left ...

ETAP: Endovascular treatment of atherosclerotic popliteal artery lesions: a prospective, multi-center, randomized study.
Introduction: The popliteal artery is a vessel considered unfavorable for the implantation of a stent due to the forces exerted in the popliteal fossa during limb flexion, which could fracture the ...

PARTNER cohort B: Clinical events at 3 years follow-up in patients with
Background: Percutaneous aortic valve implantation (TAVI) is the treatment of choice for patients with severe aortic stenosis considered inoperable according to clinical outcomes at 12 months as ...

MASTER Trial: Prospective, multicentre, randomized trial evaluating the MGuard stent in the treatment of patients with acute myocardial infarction with ST segment elevation (STEMI).
Foreword: The EPS MGUARD stent (embolic protection stent) has a fine metal structure covered by a thin polyethylene fiber mesh with pores of 5 microns wrapping the stent that might prevent distal ...

TRILOGY ACS. Prasugrel versus clopidogrel in patients with acute coronary syndromes with non – ST segment elevation treated clinically after angiographic evaluation
Insides : 40%-60% of patients with acute coronary syndrome with non ST elevation (ACS) are treated clinically. Prasugrel proved superior to clopidogrel in patients with ACS undergoing invasive ...

FAME 2: Cost-effectiveness of FFR-guided angioplasty in patients with stable angina
Introduction: FAME study 2, presented at the European Congress of Cardiology 2012, is a multicenter study that randomized patients with stable angina FFR-guided angioplasty and optimal medical ...

POST trial: Post-conditioning effect in myocardial reperfusion with primary angioplasty.
Ischemic postconditioning obtained through reversible ischemia and reproduced during reperfusion after a prolonged ischemic injury has shown comparable effects to ischemic preconditioning in ...

ADAPT-DES: Results at 1 year of the clinical impact of hypo-responders to aspirin and clopidogrel.
Background: The ADAPT-DES registry showed a strong correlation between hypo-responders to clopidogrel and the likelihood of stent thrombosis at 30 days, while the impact of aspirin response has not ...

RESPECT: Randomized clinical trial evaluated the patent foramen oval closure vs clinical treatment in patients with cryptogenic stroke
Fundamentals: Etiology of cryptogenic stroke stills a major challenge for medicine. Paradoxical embolism remains one of the possible causes. Undoubtedly, adults between 20 and 54 years represent a ...

PC Trial: Clinical treatment or closure of patent foramen oval in cryptogenic stroke patients?
Background: The association between paradoxical embolism, including cryptogenic stroke, and the presence of patent foramen oval (PFO) has been found in previous clinical studies. However, the ...

POSEIDON study: A prospective, randomized, single-center study comparing a sliding-scale hydration strategy for the prevention of contrast-induced nephropathy.
Background: Contrast-induced nephropathy has been the subject of many studies not only because of the morbidity associated with prolonged hospital stay, (with dialysis requirement in some cases), ...

AIDA STEMI MRI: Intracoronary versus intravenous abciximab in primary angioplasty. MRI analysis in AIDA study
Basics: Recent meta-analysis showed benefits of intracoronary abciximab administration compared with intravenous (A-EV). Although the AIDA study showed no such benefit when analyzing the combined ...

XIMA: Randomized prospective study comparing everolimus eluting stents versus conventional stent implantation in octogenarians.
Background: Octogenarian patients represent an increasingly growing population. In addition, this age group has a higher proportion of co-morbidities with more extensive and complex coronary ...

ISAR-DESIRE 3: A paclitaxel eluting balloon versus Taxus in the treatment of eluting stent restenosis.
Fundamentals. Background: Although we've had more than a decade of experience with implanting drug-eluting stents, (DES), the best treatment for restenosis on these devices remains unknown. The ...

STEMI RADIAL A prospective, randomized trial which compares radial versus femoral access in patients with ST- segment elevation acute myocardial infarction.
Fundamentals: Previous studies have shown the benefits of a transradial approach in the context of coronary syndromes with ST-segment elevation. The aim of this study was to evaluate these benefits ...

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