APPOSITION IV: self-expanding DES in acute coronary syndrome

This study was designed to compare the apposition and neointimal coverage of struts by optical coherence tomography (OCT) of the new self-expanding sirolimus  eluting stent (STENTYS SES) at 4 and 9 months in patients with STE-ACS. 152 patients randomized to STENTYS SES (n = 90) versus zotarolimus-eluting balloon-expandable stent (n = 62) were included. The clinical and angiographic characteristics were similar between groups. At 4 months, bad strut apposition was lower in the STENTYS SES group (0.07 versus 1.16, p = 0.002) with 33.8% of covered struts versus 3.8% in the control group only. At 9 months, mal apposition remained lower with STENTYS SES but without reaching statistical significance. No differences in MACE, stroke, stent thrombosis and target vessel revascularization were observed. 

Conclusion 

A 4-month self-expanding sirolimus  eluting stent  showed better apposition than zotarolimus-eluting balloon-expandable stent. 

Robert-Jan van Geuns
2014-05-20

Title: APPOSITION IV: Randomised comparison between a self-apposing sirolimus-eluting coronary stent and a balloon-expandable stent in acute myocardial infarction

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