BuMA stent: new sirolimus-eluting stent with bio-degradable polymer

Uncovered struts compromise re-endothelization and may induce thrombosis. The new stent approved in China and already used in more than 50,000 patients, is a sirolimus-eluting device with a bio-degradable polymer. Animal studies showed rapid and complete endothelialization. The study included 20 patients with stable angina randomized on a 1:1 ratio to receive, in the same lesion and with an overlap, the proximal sirolimus-eluting stent and the distal everolimus-eluting stent vs the proximal everolimus-eluting stent and the distal sirolimus-eluting stent. The primary endpoint was the coverage of struts after three months and the secondary endpoint was the anual coverage and the clinical events. 

After 3 months, there was no difference in relation to the coverage of struts and intimal thickness between the two stents. There was a difference was observed in luminal loss (everolimus 11.3 ± 4.1 mm vs. sirolimus 10.3 ± 3.8 mm, p<0.001), poor apposition (everolimus 0.4% vs. sirolimus 0.1%, p<0.001). These results were maintained after 12 months. The struts of the stents were found well covered after 3 and 12 months, with a difference in favor of the sirolimus-eluting stent (99.2% vs 98.2%, p<0.001). 

Conclusion: the BuMA sirolimus-eluting stent presents an earlier endothelization than the everolimus-eluting stent.

jingbo_hou_europcr
Jingbo Hou
2013-05-22

Título original: A prospective randomised controlled 3- and 12-month OCT study to evaluate the endotelial healing between a novel sirolimus-eluting stent BuMA and an everolimus-eluting stent XIENCE V.

More articles by this author

REPRISE II: results obtained with the new valve according to VARC criteria

The objective was to evaluate the safety and efficacy of the Lotus Valve System to treat patients with severe aortic stenosis and high surgical...

DEFLECT I: cerebral protection device in TAVI

Strokes after TAVI occur in between 3.8 and 6.7% of the cases, with new MRI lesions being almost the rule. The TriGuard EDD device...

DISCOVER: new low profile valve with little post-implant regurgitation

The objective of the study was to assess events after 30 days with the DirectFLOW Medical Valve device in patients with severe aortic stenosis...

JUPITER: transapical TAVI device

We evaluated 88 consecutive patients (at this phase) with severe aortic stenosis who received the second-generation device for transapical access. Survival at thirty days...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

Long Term Results of the International Chimney Registry

The International Chimney Registry was an observational study aimed at assessing the use of chimney stenting during TAVR either to predict or treat coronary...

CANNULATE TAVR extended study: Impact of Commissural and Coronary Alignment in Coronary Cannulation Following TAVR with Evolut Fx

The new valve Evolut FX has shown better commissural alignment vs. its predecessor Evolut Pro+. Prior studies have already shown commissure alignment facilitates post...

TRISCEND II: Transcatheter Replacement vs. Medical Treatment for Tricuspid Regurgitation

The EVOQUE device is designed with an intra-annular sealing system that provides excellent anatomical compatibility and an adaptable shape. It is currently available in...