CLI-OPCI: Optical coherence tomography (OCT)-guided stent implantation vs. conventional angiography guided angioplasty.

CLI-randomized study CLI-OPCI (n = 670, 1:1) evaluated the impact of stent implantation guided by angiography and optical coherence tomography (OCT), versus angioplasty guided alone by angiography. All patients who had been subjected to stent placement were then evaluated by angiography. 

Arm OCT, after an optimal angiographic result, an intracoronary OCT evaluation was performed. In the event of OCT suboptimal results, an intervention was indicated (post-dilation or additional stent implantation). 

The definition of suboptimal results was based on 5 parameters:

1) Edge dissection > 200 microns and longer than 600 microns.

2) Poor stent apposition.

3) Sub-expanding stent (<90% compared with reference segment proximal and distal).

4) Presence of thrombus.

5) Significant residual stenosis (in-stent minimum luminal area

The primary endpoint was based on a combined rate of cardiac death or non-fatal MI at 12 months follow up. In the OCT group, after an acceptable angiographic result, use of OCT identified one of the 5 parameters in 34.7% of cases -“indicating” an intervention- (post-dilation or additional stent implantation). At 12 months, the combined rate of cardiac death and myocardial infarction was lower in the OCT group (6.6 vs. 13%, p = 0.006), at the expense of a lower rate of death in this group (1.2 vs. 4.5%, p = 0.01). No difference in reoperation rates of target vessel and definite stent thrombosis was observed. 

These findings suggest:

More articles by this author

DISCOVER FLOW: Correlation of conventional FFR vs non invasive FFR obtained with MSCT for successful stenting.

The DISCOVER FLOW trial has recently showed an excellent correlation between fractional flow reserve values (FFR) traditionally obtained with coronary CT angiography (CCTA) and...

TROFI: Minimal intra-stent flow area in STEMI patients post primary PCI with or without manual thrombus aspiration.

Professor Serruys presented the results of the TROFI trial that compares the minimal intra-stent flow area in STEMI patients post primary PCI with or...

DESolve I FIM: Evaluation of a FIM trial results of a bioabsorbable stent (15 patients).

 This trial is a prospective evaluation of DESolveTM bioabsorbable coronary stent implantation in a 15 patient cohort enrolled in New Zealand and Belgium. At...

SMART: Manual Thrombectomy vs. Rheolytic Aspiration in ST-segment Elevation Acute Myocardial Infarction.

Dr. David Antoniucci presented the immediate results of randomized trial SMART SMART (n=80, 1:1) comparing manual thrombectomy (MAT) vs. rheolytic aspiration (RT) in the...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

ACC 2025 | FAME 3: FFR Guided PCI vs CABG 5 Year Outcomes.

Earlier studies comparing percutaneous coronary intervention (PCI) vs coronary artery bypass graft (CABG) have shown fewer events at long term for the surgical strategy.  However,...

ACC 2025 | API-CAT: Reduced vs. Full Dose Extended Anticoagulation in Patients with Cancer Related VTE

The risk of cancer related recurrent venous thromboembolism (VTE) will drop over time, while bleeding risk will persist. At present, it is recommended we...

STRIDE: Semaglutide in Patients with Peripheral Arterial Disease and Type II Diabetes

Peripheral arterial disease (PAD) is a severe complication in patients with type II diabetes, primarily affecting peripheral vessels, especially below-the-knee (BTK) arteries. This condition...