CORP-2 Trial: Colchicine effective in reducing the recurrence of pericarditis associated withconventional anti-inflammatory pattern.

Colchicine is effective in treating an acute pericarditis event and initial recurrences;however, there is no conclusive data on its efficacy and safety in the treatment of multiple recurrences. 

240patients were randomized to colchicine plus conventional anti-inflammatory scheme (aspirin, ibuprofen or indomethacin). The primary endpoint was the rate of recurrence of pericarditis in 18 months. The recurrence of pericarditis was 21.6% in the colchicine group and 42.5% in the placebo group (p = 0.0009) with 5 patients needed to treat. 

Conclusion

Colchicine added to conventional anti-inflammatory treatment reduced the rate of subsequent recurrences of pericarditis in patients with multiple recurrences. 

Article

Editorial

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Massimo Imazio
2014-03-31

Original title: Efficacy And Safety Of Colchicine In Patients With Multiple Recurrences of Pericarditis: Results of A Multicenter, Double-blind, Placebo-controlled, Randomized Study (CORP-2 Trial).