The Global SYMPLICITY registry is a prospective, multicenter study sponsored by Medtronic to evaluate long- term renal denervation safety and effectiveness in a real-world population with refractory hypertension. It plans to prospectively include a minimum of 5000 patients with refractory hypertension in 200 centers worldwide.In the 6-month analysis of the first 1000 patients included so far, showed adverse event rate of less than 1% and the absence of renal artery stenosis related to the procedure.The reduction in systolic blood pressure over the outpatientoffice was 11.9 mmHgand reduced pressure of 24 hour ambulatory monitoring was 7.9 mmHg.
Despite the record of GlobalSYMPLICITY registry is currently the largest on denervation of the renal artery and demonstrated safety and efficacy of the device overall discussions revolve around the negative results of randomized SIMPLICITY HTN 3.
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Michael Bohm
2014-03-31
Original title: The Global SYMPLICITY Registry: Safety and Effectiveness of Renal Artery Denervation In Real World Patients With Uncontrolled Hypertension.