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ACC 2014.

American College of Cardiology Annual Congress - March 29 to 31 - Washington DC (USA)

From March 29 to 31  follow the  ACC.14 coverage courtesy of SBHCI

SYMPLICITY HTN -3: Negative results of renal denervation in patients with resistant hypertension.
Previous studies have shown that renal denervation in a 3-year period, reduced the blood pressure in resistant hypertensive patients in a sustained and meaningful way. The aim of this study was to ...

CoreValve superior to surgical aortic valve replacement in high-risk patients
The aim of this study was to compare percutaneous aortic valve replacement (TAVR) with the self-expanding Valve Core with conventional surgery in patients at high surgical risk. Patients with a ...

ALECARDIO Trial: Aleglitazar associated with severe adverse events in diabetic patients with acute coronary syndrome
This randomized, double-blind, placebo-controlled, multicenter work evaluated the potential cardiovascular reduction risk and the long-term safety profile of Aleglitazar , compared with placebo ...

GAUSS -2: Evolocumab effective in reducing LDL cholesterol in patients intolerant to statins
Adverse effects of statins are relatively common causing poor adherence to treatment and the need for interruption of about 10-20%.The Evolocumab is a fully human monoclonal antibody that ...

Global Registry SYMPLICITY demonstrated the safety of renal denervation system
The Global SYMPLICITY registry is a prospective, multicenter study sponsored by Medtronic to evaluate long- term renal denervation safety and effectiveness in a real-world population with ...

MADIT -CRT: Increased survival with resynchronization therapy plus defibrillator in patients with mild heart failure.
The MADIT -CRT study (Multicenter Automatic Defibrillator Implantation with Cardiac Resynchronization Therapy) had shown that early intervention with cardiac resynchronization therapy plus ...

LAPLACE 2: Evolocumab effective in reducing LDL associated with statins
There are several patients who do not reach recommended LDL cholesterol despite maximally tolerated doses of statins levels.The Evolocumab is a monoclonal antibody that inhibits protein converting ...

CORP-2 Trial: Colchicine effective in reducing the recurrence of pericarditis associated withconventional anti-inflammatory pattern.
Colchicine is effective in treating an acute pericarditis event and initial recurrences;however, there is no conclusive data on its efficacy and safety in the treatment of multiple ...

Negative ultrasensitive troponin T values may help discriminate patients with chest pain in the emergency
New laboratory tests can detect minimally elevated  levels few hours before regarding detection methodologies of previous generations.The hypothesis of this study is that patients with ...

Melody
The ducts of the right ventricle to the pulmonary artery are used in approximately 20 % of all patients with congenital defects including tetralogy of Fallot with pulmonary atresia , truncus ...

STABILITY Trial: Daraplabid no benefits in chronic coronary artery disease
Daraplabid is a selective oral inhibitor of lipoprotein-associated phospholipase (Lp -PLA2)which is a potential agent for reducing cardiovascular events in patients with chronic ischemic heart ...

CHOICE Trial: Same mortality, less aortic regurgitation and need for a second prosthetic for Edwards Sapien XT valve versus Medtronic CoreValve
So far, there had been no published randomized studies comparing balloon-expandable Edwards’s prosthesis and self-expandingCoreValve. The aim of this study was to compare the results between ...

GIPS -III: Metformin does not improve ejection fraction in non-diabetic patients undergoing primary angioplasty
There are experimental studies suggesting that metformin admin before and during ischemia and reperfusion could help to preserve left ventricular function regardless of glycometabolic state.In ...

American Registry for percutaneous aortic valve replacement,one-year evolution of nearly 6000 patients
TVT STS / ACC registrywas developed to obtain data from all patients undergoing percutaneous aortic valve replacement (TAVR) in the United States. The clinical outcome at 30 days was recently ...

POISE -2: Aspirin before a noncardiac surgery does not reduce the risk of death or myocardial infarction and increased bleeding.
There is great variability in the perioperative administration of aspirin (ASA) in patients undergoing noncardiac surgery, both those who had been receiving and those who not. This work included ...

STAMPEDE Trial: Bariatric surgery was superior to optimal medical therapy to glycemic control in obese type 2diabetics
In the short term, bariatric surgery showed improvement in glycemic control of obese type 2 diabetics.This study evaluated the course at 3 years of 150 obese type 2 diabetic patients randomized to ...

SIRS Trial: Methylprednisolone does not decrease mortality and increase the risk of stroke in patients undergoing cardiac surgery
Cardiac surgery with cardiopulmonary bypass results in an inflammatory response of the body that is usually associated with adverse outcome. The preventive use of corticosteroids attenuates this ...

NEXT Trial: Biodegradable polymer stent (Nobori) was similar to the permanent polymer stents (Xience / Promus) at 2 years.
This multicenter work from Japanrandomized 3200 patients to receive biodegradable polymer biolimus eluting stent (Nobori) or everolimus-eluting stent with permanent polymer (Xience / Promus). The ...

ZEUS Trial: Patients with increased risk of bleeding may benefit from eluting stents Zotarolimus
The use of drug-eluting stents versus bare metal stents is controversial in some clinical situations in patients at high risk of bleeding.This study randomized 1606 patients considered at low risk ...

HEAT PPCI: Bivalirudin raises major cardiac events and does not reduce bleeding. The most controversial and criticized study at the ACC 14.
This randomized trial of a single center with consent obtained after randomization compared the use of bivalirudin versus heparin with the use of glycoprotein inhibitors arescue only in patients ...

MSC -HF Trial: Auto mesenchymal cell transplantation may improve ventricular function in patients with heart failure of ischemic cause
This study is a phase 2, randomized 2:1, double blind, and placebo-controlled included 59 patients with advanced heart failure of ischemic etiology undergoing autologous mesenchymal cells ...

POISE -2: Clonidine does not reduce the risk of perioperative death or myocardial infarction in patients undergoing noncardiac surgery
There is some evidence that clonidine administered in small doses for short periods of time prior to noncardiac surgery would be able to prevent cardiac events .This study randomized 10010 ...

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