Article Aortic root dissection is the main cause of mortality in Marfan syndrome. Recent studies suggest that losartan could more effective to slow aortic root enlargement than beta blockers. Primary end point was rate of aortic root enlargement expressed as the change in maximum diameter indexed to body surface area at 3 years. Between 2007…
Reducing antibiotic prophylaxis: impact on endocarditis incidence.
Antibiotic prophylaxis before dental procedures has been the gold standard in preventing infective endocarditis, despite the lack of supporting evidence. In 2008, the National Institute for Health and Clinical Excellence in the UK recommended the cessation of antibiotic prophylaxis before dental procedures and other invasive procedures. Prescription rates were drastically reduced after 2008 recommendation and,…
INHERIT: Losartan in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy is the most common hereditary cardiac pathology (1/1500) and is associated to heart failure, angina, arrhythmia, and sudden death. So far, no treatment has been proved effective to control this disease. This study randomized 133 patients with hypertrophic cardiomyopathy to placebo or losartan. Primary end point was change in left ventricular (LV) mass.…
Mitral valve repair in moderate ischemic mitral regurgitation
Article Up to 50% of acute myocardial infarctions are associated to mitral regurgitation of some degree and 10% of these cases present, at least, moderate regurgitation. Ischemic mitral regurgitation is associated to an increase of mortality and morbidity. For surgical patients with moderate regurgitation, the benefits mitral valve repair remain unclear. 301 patients were randomized…