Reduction of ischemic events after 30 months of prasugrel following TAXUS stent implantation
Article The TAXUS Liberté Post Approval study included patients treated with TAXUS paclitaxel DES receiving prasugrel for 12 to 30 months. Primary end point was a combination of death, ...

ISAR-SAFE: 6 vs. 12 month clopidogrel administration after DES implantation
The aim of this randomized double blind control trial was to validate the safety and efficacy of 6 months vs. 12 months clopidogrel treatment in patients receiving DES. Primary end point was a ...

DAPT TRIAL: double antiaggregation remains controversial
Article This multicenter randomized control study with placebo was designed to determine the risks and benefits of double antiaggregation for longer than 12 months post DES stenting. 9961 ...

ITALIC PLUS: 6 months of double antiaggregation for no less than 24 months
Article This multicenter study included patients receiving the second generation stent XIENCE V (Abbott Vascular) randomized to 6 and 24 months of double antiaggregation therapy after ...

Coronary flow reserve is associated to adverse events regardless angiographic severity.
This study included 329 consecutive patients derived to coronary angiography based on myocardial perfusion tests or PET scan (positron emission tomography). The extension and severity of heart ...

Improved survival after out-of-hospital cardiac arrest with the use of automated external defibrillators
This study included patients presenting out of hospital cardiac arrest between 2006 and 2012 in The Netherlands to assess the impact of automated external defibrillators (AED). Survival rate and ...

PARAMEDIC: mechanical vs. manual chest compressions for out of hospital cardiac arrest
Mechanical compression devices could solve manual resuscitation shortcomings and help maintain its quality. This study compared the mechanical chest compression device LUCAS-2 with manual ...

Association between hospital performance and after in-hospital cardiac arrest care
There is significant variation in survival rates after in-hospital cardiac arrest care. It is not clear whether better care is associated to better outcomes. Hospital performance was assessed ...

Low doses of aspirin for primary prevention in elderly patients with multiple risk factors.
Article The goal of this study was to assess the efficacy of low doses of aspirin (AAS) for primary prevention of cardiovascular events in Japanese elderly patients with multiple risk factors ...

ODYSSEY ALTERNATIVE: Monoclonal antibody alirocumab vs. ezetimibe in patients with statin intolerance
Statin intolerance limits patients’ capacity to reach their LDL goals. This study compared the new drug alirocumab vs. ezetimibe in patients with statin intolerance and muscular symptoms ...

FACTOR 64: Routine coronary CT angiography in patients at high risk for heart disease.
Article 900 patients with asymptomatic diabetes mellitus were randomized to CT angiography vs. Standard management. Primary end point was a combination of death, infarction and unstable angina. ...

IMPROVE-IT Trial: Finally the association of ezetimibe and simvastatin reduces events vs. simvastatin monotherapy
This is a multicenter, randomized, double blind study designed to test the hypothesis that the combination of ezetimibe and simvastatin improves outcomes compared to simvastatin alone in ACS ...

Atenolol vs. Losartan in children and young adults with Marfan syndrome
Article Aortic root dissection is the main cause of mortality in Marfan syndrome. Recent studies suggest that losartan could more effective to slow aortic root enlargement than beta blockers. ...

Reducing antibiotic prophylaxis: impact on endocarditis incidence.
Antibiotic prophylaxis before dental procedures has been the gold standard in preventing infective endocarditis, despite the lack of supporting evidence. In 2008, the National Institute for Health ...

INHERIT: Losartan in hypertrophic cardiomyopathy
Hypertrophic cardiomyopathy is the most common hereditary cardiac pathology (1/1500) and is associated to heart failure, angina, arrhythmia, and sudden death.  So far, no treatment has been ...

Mitral valve repair in moderate ischemic mitral regurgitation
Article Up to 50% of acute myocardial infarctions are associated to mitral regurgitation of some degree and 10% of these cases present, at least, moderate regurgitation. Ischemic mitral ...

Long-term outcome of a biodegradable polymer compared with durable polymers in drug eluting and conventional stents – Main results of a prospective randomized study
Article Christoph A Kaiser 2014-11-20 ...

EVOLVE II TRIAL: SYNERGY everolimus-eluting stent is not inferior to Promus Element
Dean J. Kereiakes 2014-11-20 ...

AVOID: Randomized controlled trial of oxygen therapy in AMI with ST-segment elevation: Air versus oxygen in myocardial infarction
Dion Stub 2014-11-20 ...

LIFELINE STEMI ACCELERATOR TRIAL: Improving the duration of treatment of AMI can save even more lives
Matthew W Sherwood 2014-11-20 ...