There are experimental studies suggesting that metformin admin before and during ischemia and reperfusion could help to preserve left ventricular function regardless of glycometabolic state.In observational studies, the concomitant use of metformin is associated with a lower peak CK MB and troponin.380 nondiabetic patients undergoing primary angioplasty for acute coronary syndrome study with ST segment elevation were randomized to receive metformin 500 mg 2 times per day or placebo for 4 months. The primary end point of the study was the left ventricular function at 4 months measured by nuclear magnetic resonance.At 4 months, the ejection fraction in the metformin group was 53.1 % versus 54.8 % in the placebo group (p = 0.1).
Conclusion
Metformin does not improve ejection fraction in non diabetic patients undergoing primary angioplasty.
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Chris PH Lexis
2014-03-31
Original title: Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes (The GIPS-III Randomized Clinical Trial).