Patients with Marfan syndrome (connective tissue disorder) are more susceptible to aortic dilation and consequently dissection and sudden death. Current treatment recommends prophylactic surgery when it reaches a measurement between 46-50 mm (IC) or when it is > 50 mm (IIa C) associated with beta-blocker treatment. The role of losartan added to this therapy is not well established.
113 patients were randomized with a diagnosis of Marfan, aorta
The primary end point was the dilation of the aortic arch at any level at 3 years. In the follow-up MRI performed, patients treated with losartan had lower aortic arch dilation than patients in the placebo group. During follow-up, 9 patients in both groups required surgery, 2 patients developed dissection in the control group.
Conclusion:
In patients with Marfan syndrome using losartan showed a significant reduction of aortic dilatation.
Maarten Groenink
2013-09-02
Original title: COMPARE: Effect of losartan on aortic dilatation rate in adults with Marfan Syndrome
