This study included 329 consecutive patients derived to coronary angiography based on myocardial perfusion tests or PET scan (positron emission tomography). The extension and severity of heart disease was assessed by angiography, and coronary flow reserve (CFR) was measured non-invasively by PET.
After adjusting risk factors, ejection fraction, revascularization, etc, both the severity of angiographic disease and flow reserve by PET were independently associated to these events.
A significant interaction was observed (p=0.039) between coronary flow reserve and early myocardial revascularization, and low CFR patients who underwent surgery (not PCI) presented events comparable to those of patients with conserved CRF.
Conclusion
Coronary flow reserve measured with PET was associated to events regardless angiographic severity and this effect was modified with early revascularization. Diffuse arteriosclerosis and microvascular dysfunction could contribute to the physiopathology of cardiovascular mortality and cardiac failure.
7_viviany_taqueti_articulo
Viviany Taqueti
2014-11-17
Original title: Global Coronary Flow Reserve Is Associated With Adverse Cardiovascular Events Independently of Luminal Angiographic Severity and Modifies the Effect of Early Revascularization.
