Do the Best Coronary Revascularization Prior TAVR

The presence of coronary artery disease (CAD) in patients with aortic stenosis is high, reaching 50% to70% of cases. This poses a great challenge as to what strategy to use and the things we can do.

Debemos hacer la mejor revasculirazión coronaria previo al TAVIEven though it has been shown complete revascularization is beneficial, it is often difficult to achieve. Instead, reasonable incomplete revascularization should have better evolution (similar to complete revascularization) than incomplete revascularization (ICR) defined as a Residual Syntax Score (rSS) >8 in TAVR. However, there is contradicting information in TAVR.

 

A meta-analysis of 3107 patients included in 6 studies was carried out, with a follow up between 0.7 and 3 years, comparing mortality amongst patients with ICR, reasonable ICR and no CAD disease.


Read also: Elderly Patients with ACS: Clopidogrel or Reduced-Dose Prasugrel?


ICR was associated to higher global mortality, compared against the rest of the groups.  The absence of CAD presented lower mortality compared to ICR (OR 1.85; 95% CI 1.42-2.240; P<0.01), reasonable ICR (OR, 1.69; 95% CI 1.26-2.28; P<0.001) or both groups combined (OR; 1.71; 95% CI, 1.36-2.16; P<0.001).

 

In reasonable ICR patients, there were no differences with those not presenting CAD (OR, 1.11; 95% CI, 0.89-1.39; P=0.33).

 

Conclusion

These outcomes suggest that in patients with coronary artery disease undergoing TAVR, guided rSS revascularization might bring significant benefits as regards mortality. Reasonable revascularization offers a precious opportunity to improve patient prognosis.

 

Commentary

These data suggest we should make an effort to obtain the best revascularization (in one or more procedures) in patients presenting significant CAD that are TAVR candidates.

 

However, note that the present indication poses a great challenge, seeing that it is about a high risk group where most patients are elderly. This involves higher risk in complex PCI, which we should perform taking special care as regards contrast volume, vascular complications and bleeding (the latter notably improved by the use of radial access).

 

Courtesy of Dr. Carlos Fava.

 

Original title: Impact of Coronary Artery Revascularization Completeness on Outcomes of patients With Coronary Artery disease Undergoing Transcatheter Aortic Valve Replacement. A Meta-analysis of Studies Using the residual SYNTAX Score (Synergy Between PCI With Taxus and Cardiac Surgery).

Reference: Guy Witberg, et al . Circ cardiovasc Interv 2018;11:e006000.DOI: 10.1161.


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

We are interested in your opinion. Please, leave your comments, thoughts, questions, etc., below. They will be most welcome.

More articles by this author

Prospective Analysis of the Feasibility of the PASCAL System for Transcatheter Mitral Repair: OneForAll Registry

Courtesy of Dr. Juan Manuel Pérez. Mitral transcatheter edge-to-edge repair (M-TEER) is an effective option for patients with severe mitral regurgitation who are at high...

Left Bundle Branch Block after TAVR: What Is Its Impact?

Courtesy of Dr. Juan Manuel Pérez. Left bundle branch block (LBBB) is a common complication following transcatheter aortic valve replacement (TAVR), which can be either...

Multicenter Experience with 3D Intracardiac Echocardiography for Guiding Interventional Cardiac Procedures

Courtesy of Dr. Juan Manuel Pérez. Imaging techniques play a fundamental role in interventional cardiac procedures. Intracardiac echocardiography (ICE) appears as an alternative to transesophageal...

Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening

Courtesy of Dr. Juan Manuel Pérez. Despite the available long term followup data on of transcatheter aortic valve replacement (TAVR), bioprosthesis durability continues under debate....

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

ACC 2025 | FAME 3: FFR Guided PCI vs CABG 5 Year Outcomes.

Earlier studies comparing percutaneous coronary intervention (PCI) vs coronary artery bypass graft (CABG) have shown fewer events at long term for the surgical strategy.  However,...

ACC 2025 | API-CAT: Reduced vs. Full Dose Extended Anticoagulation in Patients with Cancer Related VTE

The risk of cancer related recurrent venous thromboembolism (VTE) will drop over time, while bleeding risk will persist. At present, it is recommended we...

STRIDE: Semaglutide in Patients with Peripheral Arterial Disease and Type II Diabetes

Peripheral arterial disease (PAD) is a severe complication in patients with type II diabetes, primarily affecting peripheral vessels, especially below-the-knee (BTK) arteries. This condition...