The SYNTAX trial had a 5-year follow-up, but the SYNTAXES (“ES” for extended survival) was specifically designed to find out comparative mortality of both treatments (PCI or surgery) at 10 years in patients with three vessel and/or left main lesions.
This study retrospectively compared survival data at long term of 897 patients randomized to surgery and 907 patients randomized to PCI from the original SYNTAX.
Mortality at 5 years had been 13.9% for PCI vs 11.9% for surgery (CABG) (p=0.1); the difference in favor of surgery was in the combined events rate (37.3% vs 26.9%; p<0.001).
Data at 10 years on mortality rendered parallel curves, following the prior 5-year trend (29.4% vs 25.6%; p<0.1). That is when looking at the general population, but when assessing only patients admitted for three vessel disease, we observed a trend in favor of surgery (29,2% vs 21,9%, p=0,07). This trend could not be documented in other subgroups of patients such as diabetics or patients with left main disease.
Read also: TCT 2018 | PREPARE-CALC: Rotational Atherectomy vs. Cutting Balloon in Calcified Lesions.
These outcomes can be considered exploratory since only 72% of the general populations could be followed up to 10 years.
Original title: 10- Year Survival after Bypass Surgery versus Drug-Eluting Stents: Preliminary Results of the Randomized SYNTAX Extended Survival study – “SYNTAXES”.
Presenter: Daniel J.F.M. Thuijs.
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