Is Tricuspid Regurgitation after TAVR Significant?

Courtesy of Dr. Carlos Fava.

Severe or moderate mitral regurgitation is associated to worse evolution after TAVR. However, we should not forget the tricuspid valve that, even though not extensively researched, is also associated to a negative impact in its evolution.

Más coincidencias de las esperadas entre válvulas bicúspides y tricúspidesA meta-analysis of 12 studies with a total 41485 patients was carried out.


Early mortality (up to 6 months) was 1.8 times higher with severe or ≥moderate tricuspid regurgitation (OR, 1.80; 95% CI, 1.01 to 3.19; P=0.05). Between 6 and 30 months after TAVR, it was 1.9 times higher (HR/OR, 1.96; 95% CI, 1.35 to 2.85; P = 0.0004).

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A second meta-analysis of 7 homogeneous studies was carried out and mortality between 6 and 30 months was 2.25 times higher (HR,2.25; 95% CI, 1.20–4.24; P= 0.01).



Significant tricuspid regurgitation (severe or ≥moderate) is associated to an approximate two-fold increase in early or mid-term all-cause mortality in patients with aortic stenosis undergoing TAVR.


Courtesy of Dr. Carlos Fava.


Original title: Impact of concurrent tricuspid regurgitation on mortality after transcatheter aortic-valve implantation.

Reference: Hisato Takagi, et al. Catheter Cardiovasc Interv. 2018;1–8. DOI: 10.1002/ccd.27948.

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