Surprising EXCEL Outcomes in Diabetics with Main Left Stenosis

This study especially designed to compare PCI vs. CABG in patients with left main coronary artery disease and low to intermediate Syntax score showed that 30-day and 3 -year outcomes of PCI with everolimus eluting stents vs CABG were consistent both in diabetic and non-diabetic patients.

angioplastia a tronco de coronaria izquierda vs cirugiaThe randomized EXCEL trial (Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) reports a similar combined events rate (death, myocardial infarction or stroke) at 3 years in patients with left main lesion and low to intermediate Syntax score treated with PCI or CABG. This global data (published in the New England Journal of Medicine (NEJM) in 2016 and commented on our website) could be different por diabetics, who are at higher risk and have historically seen better benefits from surgery, as showed by the vast number of prior studies.

 

This is why this EXCEL sub-study has come as a surprise, seeing as it was already pre-specified in the original protocol, which makes it more relevant than a post-hoc sub-study.


Read also: The Significance of Aetiology on Mitral Regurgitation.


The EXCEL included 1905 patients with left main coronary artery disease and low to intermediate Syntax (≤32) randomized 1:1 to PCI with everolimus eluting stent vs. CABG stratified by the presence of diabetes. Primary end point was a composite of all cause death, stroke and MI at 3 years. Outcomes were examined in 554 diabetic patients vs 1350 non-diabetic.

 

At 3 years, the combined end point was significantly higher in the diabetic population (20.0% vs. 12.9%; p<0.001). However, in the diabetic cohort, outcomes were similar with PCI and CABG (20.7% vs. 19.3%, respectively; HR: 1.03; CI 95% 0.71 to 1.50; p=0.87), and were also similar (almost identical) in the non-diabetic cohort (12.9% vs. 12.9%, respectively; HR: 0.98; CI 95%: 0.73 to 1.32; p=0.89).


Read also: Would TAVR Have a Similar Benefit in Patients with Low Flow, Low Gradient, and Preserved Ejection Fraction?


All-cause death occurred in 13.6% of patients receiving PCI vs. 9% in the CABG group (p=0.046). Regardless, diabetes had no significant interaction with any of the end point, be there primary (p=0.82) or secondary, such as death, MI or stroke at 30 days (p=0.61), or death, MI, stroke or ischemia driven revascularization at 3 years (p=0.65).

 

Conclusion

The EXCEL outcomes, both at 30 days and 3 years, were consistent both for the diabetic and the non-diabetic populations in patients receiving PCI or CABG to treat left main coronary artery disease with low to intermediate syntax score.

 

Original title: Bypass Surgery or Stenting for Left Main Coronary Artery Disease in Patients with Diabetes.

Reference: Milan Milojevic et al. J Am Coll Cardiol 2019;73:1616–28.


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

We are interested in your opinion. Please, leave your comments, thoughts, questions, etc., below. They will be most welcome.

More articles by this author

Patients at High Risk of Bleeding After Coronary Angioplasty: Are Risk Assessment Tools ARC-HBR and PRECISE-DAPT Useful?

Patients undergoing coronary stenting typically receive dual antiplatelet therapy (DAPT) for 6 to 12 months, consisting of a P2Y12 receptor inhibitor and aspirin. While DAPT...

ACC 2025 | WARRIOR: Ischemia in Women with Non-Obstructive Coronary Artery Disease

Approximately half of all women with symptomatic ischemia who undergo coronary angiography are found to have non-obstructive coronary artery disease ((ischemia and non-obstructive coronary...

ACC 2025 | FLAVOUR II: Angiography-Derived FFR-Guided vs. IVUS-Guided PCI

Physiological assessment is effective when it comes to decision-making for percutaneous coronary intervention (PCI). However, despite the available evidence, its use remains limited. AngioFFR...

ACC-2025 Congress Second Day Key Studies

BHF PROTECT-TAVI (Kharbanda RK, Kennedy J, Dodd M, et al.)The largest randomized  trial carried out across 33 UK centers between 2020 and 2024, assessing...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

TAVR in Small Annuli: What Valve Should We Use?

One of the major challenges of severe aortic stenosis are patients with small aortic annuli, defined as ≤430 mm² aortic valve area. This condition...

Patients at High Risk of Bleeding After Coronary Angioplasty: Are Risk Assessment Tools ARC-HBR and PRECISE-DAPT Useful?

Patients undergoing coronary stenting typically receive dual antiplatelet therapy (DAPT) for 6 to 12 months, consisting of a P2Y12 receptor inhibitor and aspirin. While DAPT...

ACC 2025 | WARRIOR: Ischemia in Women with Non-Obstructive Coronary Artery Disease

Approximately half of all women with symptomatic ischemia who undergo coronary angiography are found to have non-obstructive coronary artery disease ((ischemia and non-obstructive coronary...