Efficacy of Remdesivir against COVID-19

This final report published in NEJM about the efficacy of remdesivir against COVID-19 infection vs placebo showed its superiority though only in soft end points, which does not seem to modify the course of this pandemic.

Remdesivir contra el COVID-19

Multiple drugs initially promising have been shown ineffective against the new virus. The case of hydroxychloroquine resulted paradigmatic: not only was it ineffective, but also damaging. 

No antiviral agent had shown any promise so far. 

The ACTT-1 was a double-blind study, randomized and placebo controlled that tested intravenous remdesivir in adults hospitalized for COVID-19 with evidence of respiratory compromise. 

Randomization consisted of a 200 mg load of remdesivir on day 1, followed by 100 mg/day for 9 days vs. placebo for 10 days. Primary end point was time to recovery defined by hospital discharge.


Read also: Conscious Versus General Anesthesia in TAVR.


It included 1062 patients (541 receiving Remdesivir vs 521 receiving placebo).

Those in the remdesivir arm had a 10 day mean recovery time vs. 15 days in the placebo group (p<0.001).

In the different risk categories, clinical recovery was faster with remdesivir. Morality was 6.7% with remdesivir vs 11.9% at 15 days and 11.4% vs 15.2% at 29 days, respectively. 


Read also: Asymptomatic Severe Aortic Stenosis, When Should We Intervene?


Adverse events were reported in 24.6% of patients receiving remdesivir vs 31.6% of the placebo group. This speaks of drug safety.

Conclusion

Remdesivir is superior to placebo in shortening recovery in patients hospitalized for COVID-19 with respiratory compromise.

Original Title: Remdesivir for the Treatment of Covid-19 — Final Report. The ACTT-1 Study Group.

Reference: J.H. Beigel et al. N Engl J Med. 2020 Oct 8;NEJMoa2007764. doi: 10.1056/NEJMoa2007764.


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

More articles by this author

Is the Booster Dose Against COVID-19 Effective for All Ages?

The answer is incontrovertible: it is undeniably effective. For all ages, the confirmed COVID19 and severe case rates were significantly lower for patients who...

Pfizer Booster Dose Efficacy against Omicron

The BNT162b2 vaccine (Pfizer/BioNTech) has previously shown a 95% efficacy against COVID-19. This efficacy has been changing with the surge of new variants and,...

Once Again, the Omicron Variant Tests the Limits of Healthcare Systems, But with Hope

The latest significant COVID-19 variant, the Omicron, is again pushing healthcare systems around the world onto the verge of collapse, having reached over 300...

The Most Read Articles of 2021: COVID-19

A new year is coming to an end and at SOLACI we are going over the most read studies on our website, on COVID-19. Follow...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

TCT 2024 | FAVOR III EUROPA

The study FAVOR III EUROPA, a randomized trial, included 2,000 patients with chronic coronary syndrome, or stabilized acute coronary syndrome, and intermediate lesions. 1,008...

TCT 2024 | TRISCEND II

This randomized study included 400 patients; 267 were treated with EVOQUE valve and 133 with optimal medical treatment (OMT). After one-year follow-up, there were no...

TCT 2024 – ACCESS-TAVI: Comparing Percutaneous Access Closure Strategies After TAVI

Vascular access complications following transcatheter aortic valve implantation (TAVI) remain common. However, few studies compare vascular access closure methods.  Based on the CHOICE-CLOSURE and MASH...