Empagliflozin: Better Quality of Life for Patients with Cardiac Failure and Preserved Ejection Fraction

Empagliflozin has shown early and sustained improved quality of life (at least for a year) in patients with cardiac failure and preserved function.

Sorpresivo pronóstico para los infartos con coronarias normales

Patients with cardiac failure and preserved ejection fraction present a deteriorated quality of life. The EMPEROR-Preserved assessed the efficacy of Empagliflozin in several baseline health status assessments.

HRQoL was measured using the Kansas City Cardiomyopathy Questionnaire (KCCQ) at baseline between 12, 32 and 52 weeks. Patients were divided into terciles at based on the KCCQ.

Empagliflozin effects consistently reduced the risk of cardiovascular death or death for cardiac failure in all 3 terciles at baseline. 

Similar results were observed in total hospitalizations. Patients treated with Empagliflozin showed significant improvement compared against placebo. The difference became more and more obvious over time. 

At 12 weeks, there was maximum improvement with > 5 points in favor and less likely deterioration (> 5 points in the KCCQ ). Patterns were similar at 32 and 52 weeks.


Read also: ESC 2021 | Empagliflozin in Heart Failure with Reduced and Preserved Ejection Fraction.


Even though quality of life appears as a soft point to be assessed, it keeps getting stronger and stronger as doctors dedicate to patients and cultivate empathy. 

Conclusion

In patients with cardiac failure and conserved ejection fraction, Empagliflozin reduces end points such as death and hospitalization at an early stage and maintains its effect at least a year. 

Original Title: Empagliflozin, Health Status, and Quality of Life in Patients with Heart Failure and Preserved Ejection Fraction: The EMPEROR-Preserved Trial.

Reference: Javed Butler et al. Circulation. 2021 Nov 15. Online ahead of print. doi: 10.1161/CIRCULATIONAHA.121.057812. 


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

More articles by this author

STEACS and the Use of Bivalirudin vs. Heparin: In Search of BRIGHT-4 Outcomes

Various studies and registries have previously shown the impact of post-percutaneous coronary intervention (PCI) complications on the survival of patients with ST-segment elevation acute...

TAVR and Atrial Fibrillation: What Anticoagulants Should We Use?

The prevalence of atrial fibrillation (AF) in TAVR patients ranges from 15 to 30%, depending on series. This arrhythmia has been associated to higher...

Ultrathin vs Thin-Strut Stents in PCI Patients at High Bleeding Risk

Several in vivo studies have shown that ultrathin stents present lower thrombogenic risk vs. thin-strut stents, which reflects in lower rates of target lesion...

Should We Withdraw Anticoagulation Before TAVR?

Approximately one-third of patients undergoing transcatheter aortic valve replacement (TAVR) have atrial fibrillation and are on oral anticoagulant (OAC) therapy. This creates a complex...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

TCT 2024 | FAVOR III EUROPA

The study FAVOR III EUROPA, a randomized trial, included 2,000 patients with chronic coronary syndrome, or stabilized acute coronary syndrome, and intermediate lesions. 1,008...

TCT 2024 | TRISCEND II

This randomized study included 400 patients; 267 were treated with EVOQUE valve and 133 with optimal medical treatment (OMT). After one-year follow-up, there were no...

TCT 2024 – ACCESS-TAVI: Comparing Percutaneous Access Closure Strategies After TAVI

Vascular access complications following transcatheter aortic valve implantation (TAVI) remain common. However, few studies compare vascular access closure methods.  Based on the CHOICE-CLOSURE and MASH...