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AHA 2013.

The full coverage of AHA 2013, that takes place in Dallas City from November 17th to 19th

NIAMI: Nitroprusside infusion prior to primary angioplasty
The phenomenon of reperfusion injury is responsible for 50 % of the final infarct size. Several pharmacological and non-pharmacological agents administered before or during the ischemic period ...

TTM: Hypothermia after cardiac arrest does not offer benefits
Previous studies evaluated therapeutic hypothermia (32 ° C to 34 ° C for 12-24 hours) in patients who remain unconscious after resuscitation from cardiac arrest showing improvement in ...

Mild hypothermia in pre-hospital phase after cardiac arrest
Hypothermia in the hospital phase at 32-34 ° C improves neurological outcome in patients resuscitated after ventricular fibrillation out of the hospital environment. In a normal brain ...

CATIS: Immediate reduction in blood pressure demonstrated no benefit in acute stroke
It is shown that hypertension is associated with the occurrence of stroke but immediate treatment for an acute stroke itself is unclear. This study randomized 4071 acute stroke patients enrolled ...

Plastic versus mitral valve replacement in ischemic mitral regurgitation
Unlike degenerative mitral insufficiency, ischemic failure is due to an increase in the left ventricular cavity, the loss of its elliptical form, ring dilation and displacement of the papillary ...

TOPCAT: Spironolactone in heart failure with preserved ejection fraction
The aldosterone blockade has shown benefit in the treatment of heart failure with systolic dysfunction after stroke. The aim of this study was to evaluate the effect of spironolactone in patients ...

VISTA 16: anti-inflammatory agent in acute coronary syndromes
There is evidence that inflammation would have an impact on the prognosis of patients experiencing acute coronary syndromes . The phospholipase A2 inhibitor Varespladib has positive effects on ...

Promoting cardiovascular health in the preschool age
Cardiovascular disease is the worldwide leading cause of death. Changes in lifestyle, diet and sedentary routine have increased risk factors. The age between 3 and 5 years is a great opportunity ...

MICROCLINIC: A healthy lifestyle can influence others
This randomized study conducted in a rural area consisted of an educational program of 9-10 months to encourage healthy habits versus the local standard health system. Participants should try to ...

HF ROSE: Dopamine and Neseritide in heart failure associated with renal dysfunction
Previous small studies have suggested that low-dose dopamine or neseritide can enhance congestive signs of acute heart failure without altering renal function. 360 patients were included within ...

MINERVA trial: DDDR versus DDDRP-MVP in patients with bradycardia
The sinus node disease is approximately 50 % of pacemaker implants. Atrial fibrillation is a frequent comorbidity of pacemakers and is associated with heart failure, stroke and death. While ...

COAG Trial: Dose of warfarin and Pharmacogenetics
Observational studies identified two genes that influence the dose of warfarin (CYP2C9 and VKORC1). The clinical utility of dose adjustment by genetics has been tested only in small studies with ...

CORAL: Angioplasty versus medical treatment of renal artery stenosis
Atherosclerotic stenosis of the renal artery is common in the elderly population. Previous clinical trials showed no benefit with angioplasty in relation to renal function but their use for ...

STREAM Trial: Pharmacological-invasive strategy versus primary angioplasty
The STREAM study (Strategic Reperfusion Early After Myocardial Infarction) that included 1891 patients gave support to the fibrinolytic infusion strategy in the ambulance in patients treated ...

ENGAGE AF-TIMI 48: Endoxaban versus warfarin in atrial fibrillation
The endoxaban is an oral direct inhibitor of factor Xa with a rapid onset of action and a half-life of 8-10 hours. Endoxaban efficacy and safety for long-term versus warfarinin patients with ...

EU-PACT: Warfarin dose guided by genotype
Anticoagulation level in response to a fixed dose of warfarin is difficult to predict at the start of therapy. The CYP2C9 gene polymorphism (involved in the metabolism of warfarin) and VKORC1 ...

RADAR AF: High-frequency ablation versus pulmonary vein isolation to treat atrial fibrillation
Atrial fibrillation is initiated by focal triggers and maintained by an atrial substrate called fractioned complex of atrial electrograms. Isolating the pulmonary veins (triggers) through a ...

ERASE: Endovascular treatment plus exercise versus exercise alone to treat claudication
Initial therapy for intermittent claudication has been historically the gear train, however, especially in recent years; the number of peripheral angioplasties has increased, proving highly ...

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