The phenomenon of reperfusion injury is responsible for 50 % of the final infarct size. Several pharmacological and non-pharmacological agents administered before or during the ischemic period could significantly reduce infarct size in experimental studies in humans, but the results were inconsistent. This study tested the hypothesis that intravenous nitroprusside infusion immediately before the opening…
TTM: Hypothermia after cardiac arrest does not offer benefits
Previous studies evaluated therapeutic hypothermia (32 ° C to 34 ° C for 12-24 hours) in patients who remain unconscious after resuscitation from cardiac arrest showing improvement in neurological recovery and survived. However, the ideal temperature is not set. This study enrolled 950 patients in 36 centers in Europe and Australia and randomized to hypothermia…
Mild hypothermia in pre-hospital phase after cardiac arrest
Hypothermia in the hospital phase at 32-34 ° C improves neurological outcome in patients resuscitated after ventricular fibrillation out of the hospital environment. In a normal brain hypothermia reduces the cerebral metabolic rate by 6% for each degree of reduction in temperature above 28 ° C. Mild hypothermia can also suppress some chemical reactions post…
CATIS: Immediate reduction in blood pressure demonstrated no benefit in acute stroke
It is shown that hypertension is associated with the occurrence of stroke but immediate treatment for an acute stroke itself is unclear. This study randomized 4071 acute stroke patients enrolled in an anti-hypertensive treatment (systolic pressure reduction by 10-25 % in the first 24 hours) versus control (stopping all antihypertensive drugs). The study included patients…