Unlike degenerative mitral insufficiency, ischemic failure is due to an increase in the left ventricular cavity, the loss of its elliptical form, ring dilation and displacement of the papillary muscles leading to the loss of coaptation the leaflets. European and American guidelines suggest the intervention on the mitral valve in patients with ischemic mitral regurgitation…
TOPCAT: Spironolactone in heart failure with preserved ejection fraction
The aldosterone blockade has shown benefit in the treatment of heart failure with systolic dysfunction after stroke. The aim of this study was to evaluate the effect of spironolactone in patients with preserved ejection fraction. This was a multicenter, randomized study that included 1722 patients in the spironolactone group and 1723 in the placebo group.…
VISTA 16: anti-inflammatory agent in acute coronary syndromes
There is evidence that inflammation would have an impact on the prognosis of patients experiencing acute coronary syndromes. The phospholipase A2 inhibitor Varespladib has positive effects on lipid and inflammatory markers. This double-blind, multicenter planned to randomize 5145 patients with acute coronary syndrome to Varespladib or placebo. The primary endpoint was a combination of cardiovascular…
MINERVA trial: DDDR versus DDDRP-MVP in patients with bradycardia
The sinus node disease is approximately 50 % of pacemaker implants. Atrial fibrillation is a frequent comorbidity of pacemakers and is associated with heart failure, stroke and death. While unnecessary stimulation of the right ventricle has a long term detrimental effect, including an increased risk of atrial fibrillation. In the ventricular pacing mode (MVP, managed…
Promoting cardiovascular health in the preschool age
Cardiovascular disease is the worldwide leading cause of death. Changes in lifestyle, diet and sedentary routine have increased risk factors. The age between 3 and 5 years is a great opportunity to intervene prospectively-effective to change lifestyle. The study was conducted in Colombia with preschool age children and intervention results were evaluated at 6-8 years…
MICROCLINIC: A healthy lifestyle can influence others
This randomized study conducted in a rural area consisted of an educational program of 9-10 months to encourage healthy habits versus the local standard health system. Participants should try to involve their relatives to change their lifestyle. The spread of healthy habits proposal led to a significant reduction in weight, waist circumference and systolic pressure…
HF ROSE: Dopamine and Neseritide in heart failure associated with renal dysfunction
Previous small studies have suggested that low-dose dopamine or neseritide can enhance congestive signs of acute heart failure without altering renal function. 360 patients were included within 24 hours of admission for heart failure with a glomerular filtration rate between 15 and 60 ml/min/1.73 m2. The primary endpoint was the improvement in the congestive signs…