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ACC.15.

American College of Cardiology Annual Congress - March 14 to 16 - San Diego, CA (USA)

PROMISE: Functional Test versus tomography for diagnosis of coronary artery disease
This is the first randomized controlled trial to compare the effectiveness of a functional test versus angiography by tomography (≥64 cuts) to diagnose coronary artery disease. The study included ...

REGULATE-PCI: REG1 with an unacceptable rate of severe allergic reactions
The aim of this study was to assess treatment with the new anticoagulant Pegnivacogin and its specific antidote Anivamersen compared with bivalirudin in patients undergoing coronary angioplasty. The ...

PARTNER to 5 years. TAVR is an effective alternative to surgery in high risk patients
This study included 699 patients with severe aortic stenosis and high surgical risk of whom 348 received transcatheter aortic valve replacement (TAVR) and 351 received surgery. Previous reports of ...

PEGASUS-TIMI 54: Ticagrelor plus ASA in stable patients
This double-blind study included 21162 patients with a history of acute myocardial infarction randomized to ticagrelor 90 mg e/12 h, ticagrelor 60 mg e/12 h or placebo. All patients received aspirin ...

CSPPT: folic acid for primary prevention of stroke
The aim of this study was to evaluate the effectiveness of supplementation with folic acid in primary prevention of stroke in hypertensive patients. Patients were randomized 1:1 to a fixed ...

EMBRACE STEMI: Bendavia a new drug to prevent mitochondrial dysfunction in AMI.
The purpose of this phase 2 study was to test the safety and efficacy of new drug bendavia to prevent mitochondrial dysfunction. It was a randomized, double-blind, placebo-controlled study enrolled ...

NOTION: TAVR in low-risk patients
The aim of this study was to compare the results of transcatheter aortic valve replacement (TAVR) versus surgery in unselected patients with severe degenerative aortic stenosis. Patients were ...

ODYSSEY LONG TERM: alirocumab reduces LDL in patients with maximum tolerated doses of statins
The aim of this study was to evaluate treatment with alirocumab a monoclonal antibody against PCSK9 receptor, compared with placebo in patients with heterozygous familial hypercholesterolemia or high ...

OSLER: Evolocumab reduces cardiovascular events compared with standard statin therapy
The aim of this study was to evaluate the safety and efficacy of long-term Evolocumab, an inhibitor of PCSK9 added to standard therapy versus standard therapy alone. Patients of five works in phase ...

SCOT-HEART: Coronary angiography by tomography in patients with suspected coronary artery disease
The aim of this study was to evaluate Coronary angiography by multislice CT compared with standard therapy in patients at low or moderate risk with suggestive symptoms of coronary artery disease. ...

BEST: Similar mortality among angioplasty with DES (everolimus) and surgery
This observational registry compared the results of myocardial revascularization with angioplasty performed using everolimus-eluting stents in patients with multivessel. The primary endpoint of the ...

DANAMI3: Primary Angioplasty to culprit vessel versus multivessel guided by FFR
The aim of this study was to compare the usefulness of primary angioplasty only to culprit vessel versus complete revascularization guided by fractional flow reserve (FFR) in patients admitted ...

IMPROVE-IT: The combination simvastatin / ezetimibe reduces post SCA events
This work included 18144 patients from 39 countries that were admitted pursuing an acute coronary syndrome (with or without ST segment elevation) randomized 1: 1 to receive the combination of ...

MATRIX: The radial access reduces events, bivalirudin with mixed results
Two separate works are part of the MATRIX study investigating strategies to reduce bleeding and mortality in patients with acute coronary syndrome. The first part of the work that was simultaneously ...

TOTAL: The thromboaspiration provides no benefit in primary angioplasty
In patients undergoing ST segment elevation myocardial infarction (STEMI) who received primary angioplasty, the strategy of manual thromboaspiration routine does not reduce the risk of cardiovascular ...

After 80: The octogenarian patients with acute coronary syndrome benefit from an aggressive strategy
This work published simultaneously in The New England Journal of Medicine showed that patients over eighty years may benefit from an aggressive and invasive treatment strategy that could be ...

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