The aim of this study was to evaluate the effectiveness of supplementation with folic acid in primary prevention of stroke in hypertensive patients. Patients were randomized 1:1 to a fixed combination of enalapril 10 mg and folic acid 0.8 mg daily (n = 10,348) or only 10 mg enalapril (n = 10,354) followed at a…
EMBRACE STEMI: Bendavia a new drug to prevent mitochondrial dysfunction in AMI.
The purpose of this phase 2 study was to test the safety and efficacy of new drug bendavia to prevent mitochondrial dysfunction. It was a randomized, double-blind, placebo-controlled study enrolled 58 patients in the bendavia branch and 60 in the control branch. All patients were undergoing anterior ST segment elevation myocardial infarction with TIMI 0/1…
NOTION: TAVR in low-risk patients
The aim of this study was to compare the results of transcatheter aortic valve replacement (TAVR) versus surgery in unselected patients with severe degenerative aortic stenosis. Patients were randomized 1:1 to TAVR (n = 145) or surgical replacement (n = 135). Those of TAVR group received Medtronic CoreValve self-expanding valve. The femoral access was used…
ODYSSEY LONG TERM: alirocumab reduces LDL in patients with maximum tolerated doses of statins
The aim of this study was to evaluate treatment with alirocumab a monoclonal antibody against PCSK9 receptor, compared with placebo in patients with heterozygous familial hypercholesterolemia or high cardiovascular risk who were at the maximum tolerated dose of statins and LDL >70 mg/dl. A total of 2341 patients randomized to 150 mg alirocumab administered subcutaneously…
OSLER: Evolocumab reduces cardiovascular events compared with standard statin therapy
The aim of this study was to evaluate the safety and efficacy of long-term Evolocumab, an inhibitor of PCSK9 added to standard therapy versus standard therapy alone. Patients of five works in phase two and seven works in phase three were invited to participate in the extended program. These patients were randomized 2:1 to Evolocumab…
SCOT-HEART: Coronary angiography by tomography in patients with suspected coronary artery disease
The aim of this study was to evaluate Coronary angiography by multislice CT compared with standard therapy in patients at low or moderate risk with suggestive symptoms of coronary artery disease. 2073 patients were included in each branch with a mean follow up of 1.7 years. CT significantly increased the certainty of the diagnosis of…