The aim of this study was to assess treatment with the new anticoagulant Pegnivacogin and its specific antidote Anivamersen compared with bivalirudin in patients undergoing coronary angioplasty. The Pegnivacogin has an affinity for factor IXa with a longer shelf life to 24 hours and Anivamersen only has an affinity for Pegnivacogin. The combination of these…
PROMISE: Functional Test versus tomography for diagnosis of coronary artery disease
This is the first randomized controlled trial to compare the effectiveness of a functional test versus angiography by tomography (≥64 cuts) to diagnose coronary artery disease. The study included 10003 patients from 193 centers who were symptomatic but no previous diagnosis of coronary artery disease. The study found no difference in prognosis between patients who…
PARTNER to 5 years. TAVR is an effective alternative to surgery in high risk patients
This study included 699 patients with severe aortic stenosis and high surgical risk of whom 348 received transcatheter aortic valve replacement (TAVR) and 351 received surgery. Previous reports of the results to one, two and three years and this work published simultaneously in Lancet reports the final follow-up at 5 years. The mortality at follow-up…
PEGASUS-TIMI 54: Ticagrelor plus ASA in stable patients
This double-blind study included 21162 patients with a history of acute myocardial infarction randomized to ticagrelor 90 mg e/12 h, ticagrelor 60 mg e/12 h or placebo. All patients received aspirin and had additional risk factors such as age or diabetes. The history of infarction should be between one and three years before being included…