Patients with ST-segment elevation myocardial infarction included in the CHAMPION PHOENIX trial admitted during nights, weekends, and holidays presented the same prognosis and good clinical outcomes as those who were admitted during regular daytime hours.
Prior studies had indicated that off-hours admission was associated with worse outcomes; however, this particular analysis contradicts such a paradigm.
These findings presented by Deepak L. Bhatt at the European Society of Cardiology Congress were simultaneously published in the Journal of the American College of Cardiology.
In the main CHAMPION PHOENIX trial, the primary efficacy endpoint (all-cause death, infarction, ischemia-driven revascularization, and stent thrombosis) and the secondary efficacy endpoint (stent thrombosis at 48 hours) were found to be lower with cangrelor compared with clopidogrel.
“Off-hours” were defined as weekdays from 7 p.m. to 7 a.m., weekends, and holidays.
After a multivariate propensity-score adjustment, no differences were observed in rates of all-cause death, infarction, ischemia-driven revascularization, or stent thrombosis between “off-hours” and “on-hours”.
These data may be a result of a global quality improvement in care provided to patients admitted with ST-segment elevation myocardial infarction.
Original title: “Off-hours” versus “on-hours” presentation in ST-segment elevation myocardial infarction: findings from CHAMPION PHOENIX.
Presenter: Deepak L. Bhatt.
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