More Evidence for Short Term DAPT: Approaching “the Class Effect”

Patients at high risk of bleeding undergoing coronary angioplasty with Orsiro stent can be considered for a short dual antiplatelet scheme. 

Más stents suman evidencia al esquema corto y nos acercamos al “efecto de clase”

These data come from the SMART-CHOICE study recently published in JAHA, adding the Orsiro stent to the list of devices supporting 3-month DAPT. 

This study included 2993 patients undergoing coronary angioplasty randomized to 3 moth DAPT followed by P2Y12 inhibitor monotherapy vs 12-month DAPT. 

The original protocol prespecified an analysis of Orsiro patients. In addition, a post hoc analysis compared the Orsiro against the everolimus DES. 

Of the 972 patients receiving the Orsiro, 481 were randomized to a short scheme and 491 to a 12-month DAPT.


Read also: Pleiotropic Effect of Metoprolol: Different From other B-blockers.


After a year, target vessel failure rate (composite of cardiac death, vessel related MI and target vessel revascularization) occurred in 1.7% of patients in the short scheme group vs. 2.9% pf patients in the 12-month group (HR, 0.58; CI 95%, 0.24 to 1.39; p=0.22).

In the general population receiving 3-month DAPT (n=1495) there were no differences in primary end point between patients receiving the Orsiro vs  those receiving the everolimus DES (1.7% versus 1.8%; HR, 0.96; 95% CI, 0.41-2.22; P=0.92).

The Leaders Free study (NEJM 2015) pioneered the efficacy and safety of the polymer-free Biofreedom in a population at high risk of bleeding with a short scheme of just one month DAPT.


Read also: N95 and Surgical Face Mask Sterilization Is Feasible.


Only recently have we found some alternatives to the Biofreedom to treat these patients. It might be just a question of time for us to adopt a short DAPT scheme for all contemporary stents. 

Conclusion

In patients receiving the Orsiro stent, clinical events at one year are similar between patients receiving 3-month DAPT followed by monotherapy with a P2Y12 inhibitor vs 12- month DAPT. In the group with the short scheme, events rate resulted practically identical between the Orsiro and the everolimus DES groups.

JAHA.120.018366frer

Original Title: Safety of 3-Month Dual Antiplatelet Therapy After Implantation of Ultrathin Sirolimus- Eluting Stents With Biodegradable Polymer (Orsiro): Results From the SMART-CHOICE Trial.

Reference: Kyeong Ho Yun et al. J Am Heart Assoc. 2021;10:e018366. DOI: 10.1161/JAHA.120.018366.


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

More articles by this author

Coronary Artery Disease in Aortic Stenosis: CABG + SAVR vs. TAVR + PCI: Data from Spanish Centers

Multiple randomized studies have shown comparable or superior efficacy of transcatheter aortic valve replacement (TAVR) vs. coronary artery bypass graft (CABG).  However, many of...

Evolution of Small Balloon-Expandable Valves

Small aortic rings (20 mm) have posed a significant challenge for both surgery and transcatheter aortic valve implantation (TAVI) due to their association with an...

TCT 2024 | FAVOR III EUROPA

The study FAVOR III EUROPA, a randomized trial, included 2,000 patients with chronic coronary syndrome, or stabilized acute coronary syndrome, and intermediate lesions. 1,008...

TCT 2024 – ECLIPSE: Randomized Study of Orbital Atherectomy vs Conventional PCI in Severely Calcified Lesions

Coronary calcification is associated with stent under-expansion and increased risk of both early and late adverse events. Atherectomy is an essential tool for uncrossable...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

Severe Tricuspid Regurgitation: Surgical vs. Transcatheter Edge-to-Edge Repair

While highly prevalent, tricuspid regurgitation is a notably undertreated valvulopathy. Its progression has been associated with higher mortality and significant disability. According to the...

ACCESS-TAVI: Comparing Post TAVR Vascular Closure Devices

Transcatheter aortic valve replacement (TAVR) is a well-established option to treat elderly patients with severe symptomatic aortic valve stenosis. Technical advances and device development...

Endovascular Treatment of Iliofemoral Disease for the Improvement of Heart Failure with Preserved Ejection Fraction

Peripheral artery disease (PAD) is a significant risk factor in the development of difficult-to-treat conditions, such as heart failure with preserved ejection fraction (HFpEF)....