Ten Commandments for 2021 Guidelines on Valvular Heart Disease

Nuevas guías de valvulopatías con actualizaciones clave en TAVI e insuficiencia mitral

Since the latest version to the Valvular Heart Disease Guidelines from the European Society of Cardiology, plenty of evidence has been accumulating, finally leading to this updated version. 

In this regard, below you will find what has been called “10 commandments” that sum up this new document, to keep you in the loop. 

  • The incidence of degenerative valvulopathy continues to increase in industrialized countries, with the elderly as the most affected seeing as they present multiple comorbidities. On the other hand, rheumatic heart disease continues to be fairly frequent in developing countries. 
  • We give emphasis to patient centered assessments. When considering an intervention, we should assess patient expectations and values. This can only be carried out by a multidisciplinary team working in a specialized heart valve center. 
  • Echocardiograms are key to the diagnosis of valvulopathy, to measure severity and establish prognosis. Other studies such as CT scans, MRIs and biomarkers are starting to play a more central role. 
  • Based on randomized trial outcomes on its intervention, we have new definitions of severity in secondary mitral valve regurgitation.  
  • To prevent stroke in patients with atrial fibrillation, we recommend direct anticoagulants in patients with aortic stenosis, mitral or aortic regurgitation and patients with bioprosthesis 3 months post implantation. We recommend single antiaggregation for patients undergoing TAVR with no other anticoagulation indication. 
  • In places with high surgical experience and post operative support, you can consider early intervention in asymptomatic patients at low risk of aortic stenosis, aortic or mitral regurgitation, or tricuspid regurgitation. 

Read also: New Valvular Heart Disease Guidelines with Key TAVI and Mitral Regurgitation Updates.


  • New information on randomized controlled trials comparing TAVR against CABG have contributed to clarify the role each procedure has in the treatment of low-risk patients. Choosing the most adequate strategy (TAVR vs CABG) should be in the hands of a multidisciplinary team who will consider patient age, surgical risk, clinical and anatomical characteristics (particularly femoral approach feasibility) center experience and results and, last but not least, patient preference. 
  • Edge to Edge repair has been compared to optimal medical treatment in secondary mitral regurgitation, resulting in an upgraded recommendation of this strategy for patients meeting the criteria that predict clinical improvement. 
  • A lot of information has been published on valve in valve; this has led to upgrading its recommendation. 
  • Lastly, encouraged by the published information, there is a potential role for transcatheter tricuspid repair in inoperable asymptomatic patients with tricuspid failure

Original Title: The “ten commandments” for the 2021 ESC/EACTS Guidelines on valvular heart disease.

Reference: Alec Vahanian et al. Eur Heart J. 2021 Nov 1;42(41):4207-4208. doi: 10.1093/eurheartj/ehab626.


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

More articles by this author

Embolization of Left Atrial Appendage Closure Devices: Predictors, Prevention, and Management Strategies

Atrial fibrillation is associated with an increased risk of stroke and, in patients with contraindications to anticoagulation, percutaneous left atrial appendage closure represents an...

Coronary revascularization before TAVI: prior PCI or conservative management?

The coexistence of coronary artery disease (CAD) in patients with severe aortic stenosis undergoing TAVI is common, with a reported prevalence ranging from 30%...

Percutaneous Mechanical Aspiration versus Surgical Treatment of Tricuspid Valve Endocarditis

Tricuspid valve infective endocarditis (TVIE) accounts for approximately 5% to 10% of all cases of infective endocarditis. Surgical treatment remains the standard therapy in...

CRT 2026 | TAVI-CLOSE Trial: Dual Suture vs Suture + Plug for Vascular Closure After Transfemoral TAVI

The transfemoral approach is the predominant strategy for transcatheter aortic valve implantation (TAVI). Although vascular complications are currently less frequent, they remain relevant determinants...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

ACVC 2026 | CELEBRATE Trial: Prehospital Zalunfiban Use in STEMI

Optimizing antithrombotic therapy in the prehospital phase of ST-segment elevation myocardial infarction (STEMI) remains challenging due to the delayed onset of action of P2Y12...

ACVC 2026 | BOX Substudy: Mean Arterial Pressure Targets in Cardiogenic Shock After OHCA

Hemodynamic management of cardiogenic shock following ischemic out-of-hospital cardiac arrest (OHCA-AMICS) remains an unresolved issue, particularly regarding optimal mean arterial pressure (MAP) targets and...

ACVC 2026 | FLASH Registry European Cohort: Mechanical Thrombectomy in Pulmonary Embolism

The management of intermediate-high and high-risk pulmonary embolism (PE) remains an area of therapeutic uncertainty, particularly in patients with right ventricular (RV) dysfunction, in...