Do Men and Women Present the Same Evolution after Left Atrial Appendage Closure?

Atrial fibrillation is a very frequent type of arrythmia that affects both men and women alike. This entity is associated to higher mortality seeing as it favors stroke and hospitalization for cardiac failure. 

El cierre de orejuela es seguro con los nuevos dispositivos

At present, one of its valid treatment strategies is left atrial appendage closure, to reduce or prevent stroke and anticoagulation driven bleeding. 

Sex differences in its outcomes and evolution have not yet been looked at. 

This was a meta-analysis of 6 studies including 64,035 patients. 26,120 were women (40.8%) and  37,915 were men.

Compared against men, women had more paroxysmal atrial fibrillation (57.7% vs. 48.2%, p < 0.001) and less diabetes (33.5% vs. 38.7%, p < 0.001), coronary artery disease (35.0% vs. 55.6%, p < 0.001), cardiac failure (33.1% vs. 37.8%, p < 0.001) and kidney failure (13.3% vs. 16.9%, p < 0.001).

The Watchman was used in 4 of the 6 studies, the Amplatzer in one another, and the remaining study used Watchman, Amplatzer, Lariat, Lambre, and Occlutech.

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There were no differences in procedural success (odds ratio [OR]: 0.98, 95% confidence interval [CI]: 0.89–1.09, p = 0.77), but women presented 78% more pericardial complications (OR: 1.78, 95% CI: 1.58–2.01, p < 0.00001), twice as high bleeding rate (OR: 2.04, 95% CI:1.75–2.39, p < 0.00001) and 1.7 times more vascular complications OR: 1.75, 95% CI: 1.41–2.17,p < 0.00001).  

At 2-year followup, there were no differences in mortality or stroke. 


Despite having the same procedural success, women have significantly higher incidence of pericardial complications, major bleeding and vascular complications with left atrial appendage closure. Long term followup showed no difference in mortality or stroke between men and women. 

Dr. Carlos Fava - Consejo Editorial SOLACI

Dr. Carlos Fava.
Member of the Editorial Board of

Original Title: Sex differences on outcomes following left atrial appendage occlusion in atrial fibrillation: A systematic review and meta‐analysis

Reference: Yuansong Zhu, et al.  Catheter Cardiovasc Interv. 2022;100:612–619.

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