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HEAT PPCI: Bivalirudin raises major cardiac events and does not reduce bleeding. The most controversial and criticized study at the ACC 14.

This randomized trial of a single center with consent obtained after randomization compared the use of bivalirudin...

POISE -2: Clonidine does not reduce the risk of perioperative death or myocardial infarction in patients undergoing noncardiac surgery

There is some evidence that clonidine administered in small doses for short periods of time prior to...