Hypothermia improves myocardial ischemia in animals but studies in humans failed to demonstrate benefit to that extent.We admitted 120 patients experiencing anterior-posterior STEMI with up to 6 hours after onset, randomized to conventional invasive therapy versus conventional invasive therapy associated with hypothermia. The primary endpoint was infarct size by MRI at 4 days.There was no significant reduction in infarct size with hypothermia. The authors conducted an exploratory analysis by observing that patients with previous early myocardial infarction will beaided.
David Erlinge
2013-10-31
Original title: CHILL-MI: A Prospective, Randomized Trial of Therapeutic Hypothermia in Patients with Acute Myocardial Infarction Undergoing Primary PCI
