The incidence of asymptomatic pericardial effusion after cardiac surgery is high. The aim of this study was to evaluate whether colchicine would be able to reduce the volume of postoperative pericardial effusion. This multicenter, double-blind, placebo-controlled study, randomized 197 patients with high risk of cardiac tamponade determined by the presence of persistent pericardial effusion from moderate to severe for more than 7 days after surgery using 1 mg colchicine versus placebo. At 14 days after randomization, no difference was observed in the volume of effusion or tamponade incidence between the two branches.
Philippe Meurin
2014-08-31
Original title: Colchicine for Post- operative Pericardial Effusion: The post-operative pericardial effusion (POPE-2) Study. A multicenter, double-blind, randomized trial.
