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PRIMA: Closure of patent foramen ovale in patients with migraine with aura refractory

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It is hypothesized that the presence of a right-left shunt can trigger migraine attacks. The aim of this study was to evaluate whether the closure of a patent foramen ovale may help treat patients with migraine with aura refractory to treatment. A total of 107 patients were included; 53 in the group of foramen ovale closure with Amplatzer PFO Occluder device and 41 in the medical treatment group. At one year there were no differences observed between the two groups in the number of migraine episodes although the group receiving device closure presented a more spaced frequency and lower intensity. 

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David Hildick-Smith
2014-09-17

Original title: A Prospective, Randomized Trial of PFO Closure in Patients with Refractory Migraine with Aura

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