A small number of highly selected patients presents good outcomes with new bioresorbable scaffold MeRes, but much more evidence is necessary to bring back the concept.
The MeRes-1 study tested the newest generation of the Meril Life Sciences bioresorbable scaffold, a device featuring thinner struts compared with Absorb (from 150 µm in Absorb to only 100 µm). Results at 3 years are relatively good, with a major event rate of just 1.87%.
The study included 107 patients treated with the sirolimus-eluting scaffold and only two of them required revascularization of the target lesion.
Moreover, in the MeRes-1 Extend study, a similar trial with 62 patients, the 2-year major adverse cardiac events (MACE) rate was 1.61%, with just one case of ischemia-driven revascularization.
Significantly, no cases of thrombosis were reported in any of these works.
The MeRes scaffold has already been approved in India and received CE Mark approval for Europe a few days ago.
These are promising data mainly regarding device safety in relatively simple lesions, but there is a need for further long-term evidence comparing device efficacy and safety with that of contemporary drug-eluting stents.
Original Title: MeRes-1 Extend: imaging and two-year clinical outcomes of thin-strut sirolimus-eluting bioresorbable vascular scaffold in patients with coronary artery disease.
Reference: Abizaid A.
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