Researchers assessed a total of 120 patients with symptomatic severe functional mitral regurgitation despite receiving optimal guideline-directed medical therapy.
The average age was 65 years; 44% of subjects were women and over 80% had undergone prior hospitalization due to heart failure.
The primary endpoint (PEP) was the composite of all-cause mortality and hospitalization due to heart failure at 12 months.
The average ejection fraction was 57%, end-diastolic volume 164 mL, end-systolic volume 104 mL, end-diastolic diameter 64 mm, and effective regurgitant orifice area 40 mm². Additionally, 65% had grade 4+ mitral regurgitation, and the remainder had 3+++.
Overall, 62% of patients received a single clip, 35% received two clips, 0.8% received three clips, and implantation was not possible in two patients.
At 12 months, the PEP was 24.6%. The significant reduction in mitral regurgitation was maintained, and so was the improvement in functional class, the 6-minute walk test, and quality of life.
Presented by Georg Nickenig during EuroPCR 2025 in Paris, France.
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