Kidney Insufficiency and the Risk of Developing Aortic Stenosis in the Future

Chronic kidney disease, even in moderate or severe stages before dialysis, is associated with an increased risk of aortic stenosis according to this work recently published in J Am Coll Cardiol.

Sub análisis del EXCEL: angioplastia vs cirugía en insuficiencia renal crónicaBoth share several risk factors, something that complicates the identification of the association between these diseases due to multiple confounding variables.

 

The study included 1,121,875 Stockholm citizens without a history of aortic stenosis from the SCREAM (Stockholm CREAtinine Measurements) project. The glomerular filtration rate (mL/min/1.73 m2) was calculated from serum creatinine. The association between glomerular filtration and aortic stenosis incidence was estimated with multivariable Cox proportional hazards models.


Read also: EXCEL Sub-Analysis: Angioplasty vs. Surgery in Chronic Renal Insufficiency.


The sensitivity analysis included possible reverse causation bias (the hypothesis that aortic stenosis causes renal insufficiency) by excluding diagnosis in the first 6 months or 2 years after enrollment and excluding patients with comorbid heart failure.

 

Mean patient age was 50 years and the glomerular filtration rate was 96 mL/min/1.73 m2.

 

During a 5.1-year follow-up, 5858 (0.5%) patients developed aortic stenosis (incidence rate: 1.13/1000 years-patient).


Read also: Subclavian and Axillary Access for TAVR: a Valid Alternative.


Compared with patients whose filtration rate remained above 90 mL/min/1.73 m² (incidence rate: 0.34/1000 years-patient), as the glomerular filtration rate went down, the incidence of aortic stenosis went up. For patients with a filtration rate between 60 and 90 mL/min/1.73 m², the hazard ratio (HR) was 114 and the 95% confidence interval (CI) was 1.05 to 1.25; for patients with a filtration rate between 45 and 59 mL/min/1.73 m², the HR was 1.17 and the 95% CI was 1.05 to 1.30; for those between 30 and 44, the HR was 1.22 and the 95% CI was 1.07 to 1.39; and finally, for patients whose glomerular filtration was below 30, the HR was 1.56 and the 95% CI was 1.29 to 1.87.

 

Conclusion

Renal impairment, from moderate stages upwards, is associated with an increased risk of aortic stenosis.

 

Original title: Kidney Dysfunction and the Risk of Developing Aortic Stenosis.

Reference: Georgios Vavilis et al. J Am Coll Cardiol 2019;73:305-14.


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

We are interested in your opinion. Please, leave your comments, thoughts, questions, etc., below. They will be most welcome.

More articles by this author

ACC-2025 Congress Second Day Key Studies

BHF PROTECT-TAVI (Kharbanda RK, Kennedy J, Dodd M, et al.)The largest randomized  trial carried out across 33 UK centers between 2020 and 2024, assessing...

Prospective Analysis of the Feasibility of the PASCAL System for Transcatheter Mitral Repair: OneForAll Registry

Courtesy of Dr. Juan Manuel Pérez. Mitral transcatheter edge-to-edge repair (M-TEER) is an effective option for patients with severe mitral regurgitation who are at high...

Left Bundle Branch Block after TAVR: What Is Its Impact?

Courtesy of Dr. Juan Manuel Pérez. Left bundle branch block (LBBB) is a common complication following transcatheter aortic valve replacement (TAVR), which can be either...

Multicenter Experience with 3D Intracardiac Echocardiography for Guiding Interventional Cardiac Procedures

Courtesy of Dr. Juan Manuel Pérez. Imaging techniques play a fundamental role in interventional cardiac procedures. Intracardiac echocardiography (ICE) appears as an alternative to transesophageal...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

ACC-2025 Congress Second Day Key Studies

BHF PROTECT-TAVI (Kharbanda RK, Kennedy J, Dodd M, et al.)The largest randomized  trial carried out across 33 UK centers between 2020 and 2024, assessing...

ACC 2025 | FAME 3: FFR Guided PCI vs CABG 5 Year Outcomes.

Earlier studies comparing percutaneous coronary intervention (PCI) vs coronary artery bypass graft (CABG) have shown fewer events at long term for the surgical strategy.  However,...

ACC 2025 | API-CAT: Reduced vs. Full Dose Extended Anticoagulation in Patients with Cancer Related VTE

The risk of cancer related recurrent venous thromboembolism (VTE) will drop over time, while bleeding risk will persist. At present, it is recommended we...