Are Aortic Stenosis and Kidney Dysfunction Associated?

Courtesy of Dr. Carlos Fava.

Aortic stenosis happens in 2.8% of patients over 75, and is even more frequent in dialysis patients. However, it remains unclear whether kidney dysfunction increases the risk of aortic stenosis.

The present study looked at 1,121,875 patients from the SCREAM project (Stockholm CREAtinine Measurements).

 

Mean age was 50, and 54% of the population were women. 16.2% of patients suffered from hypertension, hyperlipidemia 9.9%, diabetes 5.5%, ischemic cardiomyopathy 5.3% and stroke 3%. Estimated glomerular filtration rate (eGFR) was 96 ml/min/1.73 m2 (IQR: 82 to 109 ml/min/1.73 m2).


Read also: Outcomes of Contemporary DES in Patients with Diabetes: Do They Render Freedom Obsolete?


Patients were divided according to GFR: 699,957 presented >90 eGFR, ml/min/1.73 m2; 354,969 between 60-90; 44,744 between 45-59; 16,611 between 30-44; and 5,594 <30.

 

Patients presenting the lowest eGFR were mostly women, had more comorbidities and required more medication.

 

Follow up was at 5.1 years. 5,858 patients developed aortic stenosis, that is, there was an incidence of 1.13 every 1000 person/year. Patients presenting eGFR >90 ml/min/1.73 m2 were 0.34 every 1000 person/year, increasing as eGFR decreased, reaching 8.27 in those presenting eGFR <30 ml/min/1.73 m2.


Read also: The Price of Binge Watching: Subclinical Atherosclerosis and Sleep Quality.


Patients with eGFR ≤44 ml/min/1.73 m2 presented approximately 20% higher risk of developing aortic stenosis, even excluding those that had had events or cardiac failure.

 

Conclusion

Moderate to severe chronic kidney dysfunction is associated to increased risk of aortic stenosis.

 

Courtesy of Dr. Carlos Fava.

 

Original title: Kidney Dysfunction and the Risk of Developing Aortic Stenosis.

Reference: Georgios Vavilis, et al. J Am Coll Cardiol 2019;73:305–14.


Subscribe to our weekly newsletter

Get the latest scientific articles on interventional cardiology

We are interested in your opinion. Please, leave your comments, thoughts, questions, etc., below. They will be most welcome.

More articles by this author

TCT 2024 | TRISCEND II

This randomized study included 400 patients; 267 were treated with EVOQUE valve and 133 with optimal medical treatment (OMT). After one-year follow-up, there were no...

TCT 2024 – ACCESS-TAVI: Comparing Percutaneous Access Closure Strategies After TAVI

Vascular access complications following transcatheter aortic valve implantation (TAVI) remain common. However, few studies compare vascular access closure methods.  Based on the CHOICE-CLOSURE and MASH...

TCT 2024 | SIRONA: Randomized Study Comparing Sirolimus-Coated vs Paclitaxel-Coated Balloon Angioplasty in Femoropopliteal Disease

This prospective, randomized, multicenter, investigator-initiated non-inferiority study compared the use of sirolimus-coated balloon (MagicTouch) vs paclitaxel-coated balloon in endovascular treatment.  The primary objective was to...

TCT 2024 | PEERLESS: Mechanical Thrombectomy with FlowTriever vs Catheter-Directed Thrombolysis in Intermediate Risk PTE

Pulmonary embolism (PE) continues to be the third cause of cardiovascular mortality. The current clinical guidelines recommend anticoagulation in intermediate risk patients presenting right...

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

SOLACI Sessionsspot_img

Recent Articles

TCT 2024 | FAVOR III EUROPA

The study FAVOR III EUROPA, a randomized trial, included 2,000 patients with chronic coronary syndrome, or stabilized acute coronary syndrome, and intermediate lesions. 1,008...

TCT 2024 | TRISCEND II

This randomized study included 400 patients; 267 were treated with EVOQUE valve and 133 with optimal medical treatment (OMT). After one-year follow-up, there were no...

TCT 2024 – ACCESS-TAVI: Comparing Percutaneous Access Closure Strategies After TAVI

Vascular access complications following transcatheter aortic valve implantation (TAVI) remain common. However, few studies compare vascular access closure methods.  Based on the CHOICE-CLOSURE and MASH...