The Most Read Scientific Articles of January in Solaci.org

01- Soon after the EXCEL “Scandal” the NOBLE 5-year Outcomes Come Out: Mere Coincidence?

There is no such thing as coincidence, at least not for the evidence-based medical science. This is what the NOBLE 5-year outcomes, soon to be published in the Lancet, seem to say, in line with the BBC exposé of the EXCEL study.

Read more HERE

02-Latest Guidelines “Dropped” After Scandal Over EXCEL Results

The European Association for Cardio-Thoracic Surgery (EACTS) formally withdrew its support for the latest coronary revascularization guidelines following a BBC investigation suggesting that data from the EXCEL trial might have been manipulated.

Read moreHERE

03- How Much Should We Exercises to Reduce Mortality?

Physical activity has been shown to reduce mortality in a dose/response manner, just like any drug. But many still wonder: are there any minimal requirements in terms of amount or intensity? Is there such a thing as “toxic exercise”? And finally, is exercising equally beneficial to all?

Read moreHERE

04-New European Guidelines for Dyslipidemia Management: What is New?

Reading clinical practice guidelines, except for specific consultation, is usually tedious. These guidelines are nor meant to be read as a textbook, or at least this is what most readers believe.

Read more HERE

05-Artificially Sweetened Beverages and Alzheimer Risk

Artificially sweetened beverages (with different kinds of sweeteners) could be responsible for increased cerebrovascular risk and close to a 3-fold increase in dementia risk due to Alzheimer’s disease.

Read more HERE

06-Egg Consumption and Mortality Due to Cardiovascular Events

According to this study recently published in prestigious journal JAMA, eating too much cholesterol or eggs (which have a high concentration of it in the yolk) is significantly associated with a higher risk of cardiovascular events and all-cause mortality, with a typical dose/effect curve. According to the authors, this information should be considered for an update of current dietary guidelines.

Read more HERE

07- The EXCEL Authors’ Answer to the BBC Investigation

Do to an investigation carried out by the BBC that led to the withdrawal of EACTS support from the latest coronary revascularization guidelines, the authors of the EXCEL study (indicated by this research) provided the following answers.

Read more HERE

08-Impella: A Revolutionary Device Being Questioned

Observational studies (with their subsequent limitations) show a possible increase in adverse events and costs with the use of the Impella device.

Read more HERE

09-Crest-2 Registry: Carotid PCI Presents Low Rates of Death and Stroke

In modern studies, carotid artery stenting (CAS) has been shown equal to surgery in terms of the composite end point of periprocedural stroke, death, acute myocardial infarction and late ipsilateral stroke. This was tested in different groups and by trained operators.

Read more HERE

10- Ticagrelor Monotherapy One Month After DES Implantation

The GLOBAL LEADERS study includes a pre-specified sub-study, GLASSY, that showed that ticagrelor monotherapy after one month of dual antiplatelet therapy is non-inferior (but not superior) to conventional treatment in terms of ischemic events. As regards safety, ticagrelor monotherapy did not decrease major bleeding compared with conventional therapy.

Read more HERE


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