IBIS 4: intensive treatment with statins after ST-segment elevation myocardial infarction

Statins may help stabilize the atherosclerotic plaque in acute myocardial infarction. 103 patients who underwent primary angioplasty followed by coronary intravascular ultrasound (IVUS) in the culprit artery and not culprit of infarction were included. Patients received 20 mg of rosuvastatin for two weeks and then 40 mg for 13 months ending up with a new IVUS. The percent of atheroma volume alteration and alteration necrotic core percentage of the plate was evaluated. A gross reduction of 0.9% was observed, after treatments with rosuvastatin in absolute numbers do not look like much but it reached statistical significance. 

Original title: Effect of high-intensity statin therapy on atherosclerosis in patients with ST-elevation myocardial infarction. Results of the prospective, longitudinal intravascular ultrasound follow-up study. IBIS 4.