Stroke Rate after CABG vs PCI in over 10,000 Patients

Repeat revascularization rate has historically been the weak spot of PCI when compared against CABG: we are still unable to compete with a well done internal mammary artery graft connected to the anterior descending artery.

However, repeat revascularization is the soft of end points commonly assessed in trials, and even though several studies have shown the kind of patients that most benefit from CABG in terms of death or infarction, stroke has traditionally been overlooked. Most likely, the reason we lack data on one of the hardest end points is because it is not as frequent, which is why we need a larger population, to be able to show significant differences between these strategies.

This pooled analysis including 11518 patients (5573 PCI and 5765 CABG) from 11 randomized studies, showed that at 5 years stroke rate is significantly lower with PCI. The advantage seems to be driven by periprocedural stroke common to CABG, seeing as from 30 days and up to 5 years after procedure curves remain parallel. This kind of strokes are associated to higher mortality post procedure.

Read also: Endovascular Therapy in Stroke: Much Evidence and Few Trained Operators.

The pooled analysis included old studies such as the ERACL, ARTS or MASS II, classic studies such as the SYNTAX or the FREEDOM, and more contemporary studies such as the EXCEL and NOBLE.

At 30 days, stroke rate was 0.4% in the PCI group, and 1.1% with CABG (HR 0.33, CI 95% 0.20 to 0.53; p<0.001).

At 5 year follow up, stroke rate continued to be significantly lower in the PCI group (2.6% vs. 3.2%; p=0.027), even though between day 31 and 5 years, the incidence was comparable (2.2% vs 2.1%; p=072). There were no significant interactions between baseline characteristics and stroke with the sole exception of diabetes, where patients receiving PCI were especially benefitted. (2.6% vs 4.9%).

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Patients suffering from stroke within 30 days after index procedure had higher mortality both with PCI (45.7% vs 11.1%, p<0.001) and CABG (41.5% vs. 8.9%, p<0.001).

Conclusion

This analysis is one of the largest and most representative randomized studies to compare PCI against CABG, and with a 5 year follow up it has shown that stroke is significantly lower in patients undergoing PCI, driven by a reduced risk within 30 days after procedure, seeing as after 30 days and up to 5 years later, curves remain identical. The greatest risk of stroke in CABG patients was observed with multiple vessels disease and diabetes. Presenting stroke increased mortality at follow up regardless the strategy.

Original title: Stroke Rates Following Surgical Versus Percutaneous Coronary Revascularization.

Reference: Stuart J. Head et al. J Am Coll Cardiol 2018;72:386–98.

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