Therapy in heart failure has been to focus the neurohormonal pathways such as the renin-angiotensin-aldosterone system. Natriuretic peptides are metabolized by neprilysin enzyme. The LCZ696 is a new class of drug that inhibits the enzyme neprilysin. A total of 8436 patients with chronic heart failure functional class II-IV were included, elevated levels of NT-ProBNP and/or…