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POPE-2: Colchicine to prevent pericardial effusion after cardiac surgery

The incidence of asymptomatic pericardial effusion after cardiac surgery is high. The aim of this study was...

NECTAR HF: Chronic vagal stimulation for heart failure with low ejection fraction

The increased sympathetic activity and reduced parasympathetic tone are important pathophysiological contributors to the progression of heart...

CONFIRM HF: Is it safe to replace intravenous iron in patients with chronic heart failure

This study aimed to assess whether iron replacement versus placebo could improve physical activity in patients with...

PARADIGM-HF: New family of drugs for chronic heart failure

Therapy in heart failure has been to focus the neurohormonal pathways such as the renin-angiotensin-aldosterone system. Natriuretic...