Original Title: Early Intravenous Beta-Blockers in Patients with ST-Segment Elevation Myocardial Infarction before Primary Percutaneous Coronary Intervention. Reference: Roolvink V et al. J Am Coll Cardiol. 2016 Jun 14;67(23):2705-15. The impact of endovenous beta-blockers before primary PCI has not been established yet. This is the first double blind multicenter trial, controlled with placebo, to…
SPRINT: lower blood pressure targets for many hypertensive
Original Title: A randomized trial of intensive versus standard blood-pressure control. Presenter: Wright JR Jr. A systolic blood-pressure target lower than 120 over the standard 140 mm Hg reduces adverse events rates in non-diabetic patients at high cardiovascular risk, according to the SPRINT trial, but only at the expense of increased adverse events that include hypotension,…
JUPITER Subanalysis: Reduction of LDL Determines Clinical Impact of Rosuvastatin Therapy
Original Title: Cholesterol treatment targets and clinical outcomes: a JUPITER trial update. Presenter: Paul Ridker. The lower the LDL cholesterol levels, the less adverse cardiovascular events in men and women initially healthy, according to an analysis of the JUPITER trial. Findings could help inform about the optimal LDL goals in primary prevention. To explore the…
IVUS plaque regression with high doses of statins
Original title: Effect of high-intensity statin therapy on atherosclerosis in non-infarct-related coronary arteries (IBIS-4): a serial intravascular ultrasonography study. Reference: Räber L et al. Eur Heart J. 2015 Feb 21;36(8):490-500. The long-term effect of intensive statin therapy on coronary atherosclerosis in patients admitted pursuing an ST segment elevation myocardial infarction is unknown. The aim of this study was…
Best ejection fraction using Metoprolol as pretreatment in acute myocardial infarction
Original title: Long-Term Benefict of Early Pre-Reperfusion Metoprolol Administraction in Patients With Acute Myocardial Infaction. From the METOCARD-CNIC Trial. Reference: Gonzalo Pizarro et, al. J Am Coll Cardiol 20141;63:2356-62 The anterior infarction with ST- segment elevation has a high morbidity and mortality, both in the acute phase as well as after the presence of heart failure, arrhythmias…
Riociguat, a new drug for pulmonary arterial hypertension
Título original: Riociguat for the Treatment of Pulmonary Arterial Hypertension. Referencia: Hossein-Ardeschir Ghofrani et al. N Engl J Med 2013;369:330-40. Many drugs have been tested for pulmonary arterial hypertension (PAH) including PDE5 inhibitors, prostanoids and endothelin receptor antagonists, however there are still missed targets in the treatment of this disease. Riociguat is a drug belonging to a…
High doses of statins may reduce the lipid content in severe injury
Original title: Changes in Plaque Lipid Content After Short-Term Intensive Versus Standard Statin Therapy. The YELLOW Trial (Reduction in Yellow Plaque by Aggressive Lipid-Lowering Therapy). Reference: Annapoorna S. Kini et al. J Am Coll Cardiol 2013;62:21–9. Multiple studies have shown the benefits of statins in reducing all events, stabilize plaques and improve endothelial function. Coronary intravascular ultrasound (IVUS)…
Monoclonal antibodies to decrease peri-procedural myocardial damage
Original title: Effects of the P-Selectin Antagonist Inclacumab on Myocardial Damage After Percutaneous Coronary Intervention for Non–ST-Segment Elevation Myocardial Infarction Results of the SELECT-ACS Trial. Reference: Jean-Claude Tardif et al. J Am Coll Cardiol 2013;61:2048–55. The pathophysiology of myocardial injury after angioplasty is multifactorial but it is clear that inflammation and platelet activation play a major role. P-selectin…
High doses of Rosuvastatin in acute coronary syndromes
Original title: Rosuvastatin calcium in acute coronary sydromes Reference: Aggarwal, R. et al, Expert Opinion on Pharmacotherapy , Volume 14, Number 9, June 2013 , pp. 1215-1227(13). Lowering cholesterol of low density lipoproteins (LDL-C) by reducing inhibitors of 3-hydroxy-3-metilgutaril coenzyme A (HMGCoA) statins has proven advantageous for the survival of patients with acute coronary syndrome (ACS). These patients…
Gastric bypass puts type 2 diabetes into remission
Original title: Effects of Ingestion Routes on Hormonal and Metabolic Profiles in Gastric-Bypassed Humans. Reference: Andreas Lindqvist, Peter Spégel, Mikael Ekelund, Hindrik Mulder, Leif Groop, Jan Hedenbro and Nils Wierup. . JCEM, 2013 DOI: 10.1210/jc.2012-3996. A team of researchers at Lund University has explained why gastric bypass often sends diabetes to fast remission, which could be a step…
Drugs to treat high blood pressure reduce the risk of dementia
Taking beta-blockers may help reduce the risk of dementia according to a new study. Dr. Lon White of the Pacific Health Research and Education Institute in Honolulu, Hawaii, USA, who will present the data during the 65th Annual Meeting of the American Academy of Neurology in San Diego in March, described the discovery as ‘fascinating’.…